Hepatic Macrophage as a Key Player in Fatty Liver Disease.
Hepatic Macrophage as a Key Player in Fatty Liver Disease.
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DOI：
10.3389/fimmu.2021.708978
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发表时间：
2021
影响因子：
7.3
通讯作者：
Gao L
中科院分区：
文献类型：
--
作者：
Xu L;Liu W;Bai F;Xu Y;Liang X;Ma C;Gao L
由于全球肥胖症发病率的增加，以过度炎症和脂质沉积为特征的脂肪肝正在成为全球最普遍的肝脏代谢疾病之一。然而，脂肪肝疾病的潜在机制知之甚少。越来越多的证据表明，肝巨噬细胞，特别是枯否细胞（KCs），在脂肪肝疾病的进展中起着关键作用。因此，有必要研究目前肝巨噬细胞（KCs和单核细胞衍生的巨噬细胞）的作用的证据。本文主要综述了肝脏巨噬细胞参与脂肪肝发病机制的异质性和多种模式，包括Toll样受体（TLR）、NLRP 3炎性小体、脂毒性、糖毒性、代谢重编程、与肝脏周围细胞的相互作用以及铁中毒等。更好地了解肝脏巨噬细胞在脂肪肝疾病发展中的不同作用，可能为炎症性肝病提供更特异和有前途的巨噬细胞靶向治疗策略。
Fatty liver disease, characterized by excessive inflammation and lipid deposition, is becoming one of the most prevalent liver metabolic diseases worldwide owing to the increasing global incidence of obesity. However, the underlying mechanisms of fatty liver disease are poorly understood. Accumulating evidence suggests that hepatic macrophages, specifically Kupffer cells (KCs), act as key players in the progression of fatty liver disease. Thus, it is essential to examine the current evidence of the roles of hepatic macrophages (both KCs and monocyte-derived macrophages). In this review, we primarily address the heterogeneities and multiple patterns of hepatic macrophages participating in the pathogenesis of fatty liver disease, including Toll-like receptors (TLRs), NLRP3 inflammasome, lipotoxicity, glucotoxicity, metabolic reprogramming, interaction with surrounding cells in the liver, and iron poisoning. A better understanding of the diverse roles of hepatic macrophages in the development of fatty liver disease may provide a more specific and promising macrophage-targeting therapeutic strategy for inflammatory liver diseases.
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影响因子：
5.8
作者：
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通讯作者：
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DOI：
10.1016/j.bbadis.2009.08.007
发表时间：
2009-11
影响因子：
6.2
作者：
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