Homogenization modelling of antibiotic diffusion and adsorption in viral liquid crystals.
Homogenization modelling of antibiotic diffusion and adsorption in viral liquid crystals.
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DOI：
10.1098/rsos.221120
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发表时间：
2023-01
影响因子：
3.5
通讯作者：
D'Alessandro, G.
中科院分区：
文献类型：
--
作者：
van Rossem, M. T.;Wilks, S.;Secor, P. R.;Kaczmarek, M.;D'Alessandro, G.
杆状病毒系统长期以来对活液晶科学很重要，因为它们的单分散性和均匀电荷使它们成为方便的模型系统。最近，研究表明，添加聚合物后，杆状病毒的悬浮液会形成液晶，这与细菌对抗生素的耐受性增加有关。我们使用均质化来获得描述抗生素通过这些液晶扩散的有效方程。将均质化的分析结果与精确微观模型的数值结果进行比较，显示出良好的一致性，从而使我们能够确定该过程背后的关键参数。我们的模型表明，吸附在增加抗生素扩散时间方面起着关键作用，因此向列杆状病毒的存在可能仅通过物理机制增加抗生素耐受性。这些结果证明了均质化作为液晶病毒系统分析工具的适用性，并且可以相对直接地扩展到更复杂的问题，例如液晶生物膜、其他生物液晶和具有不同类型局部结构顺序的生物系统。
Systems of rod-shaped viruses have long been important to the science of living liquid crystals, as their monodispersity and uniform charge make them convenient model systems. Recently, it was shown that, upon the addition of polymers, suspensions of rod-shaped viruses form liquid crystals that are linked with increased tolerance of bacteria against antibiotics. We use homogenization to obtain effective equations describing antibiotic diffusion through these liquid crystals. The analytical results of homogenization are compared with numerical results from an exact microscopic model, showing good agreement and thus allowing us to identify the key parameters behind the process. Our modelling shows that the adsorption plays a key role in increasing antibiotic diffusion time and therefore the presence of nematic rod-shaped viruses may increase antibiotic tolerance through physical mechanisms alone. These results demonstrate the applicability of homogenization as an analytical tool to systems of liquid crystalline viruses, with relatively straightforward extension to more complex problems such as liquid crystalline biofilms, other biological liquid crystals and biological systems with different types of local structural order.
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影响因子：
3.4
作者：
Janmey PA;Slochower DR;Wang YH;Wen Q;Cēbers A
通讯作者：
Cēbers A
影响因子：
30.3
作者：
Secor PR;Sweere JM;Michaels LA;Malkovskiy AV;Lazzareschi D;Katznelson E;Rajadas J;Birnbaum ME;Arrigoni A;Braun KR;Evanko SP;Stevens DA;Kaminsky W;Singh PK;Parks WC;Bollyky PL
通讯作者：
Bollyky PL
影响因子：
6.4
作者：
Pourtois JD;Kratochvil MJ;Chen Q;Haddock NL;Burgener EB;De Leo GA;Bollyky PL
通讯作者：
Bollyky PL
DOI：
10.1142/s0218202520500086
发表时间：
2020-02-01
影响因子：
3.5
作者：
Canevari, Giacomo;Zarnescu, Arghir
通讯作者：
Zarnescu, Arghir
DOI：
10.1073/pnas.1917726117
发表时间：
2020-03-03
影响因子：
11.1
作者：
Tarafder, Abul K.;von Kugelgen, Andriko;Bharat, Tanmay A. M.
通讯作者：
Bharat, Tanmay A. M.