Effect of a Toothpaste Containing Surface Pre-Reacted Glass-Ionomer Filler on the Remineralization of Artificial Carious Enamel Lesions in situ
Effect of a Toothpaste Containing Surface Pre-Reacted Glass-Ionomer Filler on the Remineralization of Artificial Carious Enamel Lesions in situ
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含有表面预反应玻璃离子填料的牙膏对人工龋牙釉质原位再矿化的影响
DOI：
10.1159/000527388
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发表时间：
2022
期刊：
影响因子：
4.2
通讯作者：
A. Magalhães
中科院分区：
文献类型：
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作者：
M. Vertuan;Júlia França da Silva;Amanda Moura Ferreira;A. S. Braga;A. Magalhães
本研究评价了含有表面预反应玻璃离子（S-PRG）填料的牙膏对脱矿牙釉质的原位矿化作用。为此，180个牛牙釉质样品通过使用微宇宙生物膜模型脱矿3天。此后，将样本随机分配给15名健康志愿者，并分配给3个交叉原位阶段，对应于以下治疗：（1）含1，500 ppm氟的牙膏（NaMFP）（阳性对照，高露洁®防蛀剂），（2）含5% S-PRG填充剂的牙膏（Shofu®），以及（3）安慰剂牙膏（由Shofu®制备的阴性对照）。每个阶段将四个脱矿釉质块固定到每个腭矫正器中。受试者佩戴5天，每天刷牙2次，每次2分钟，同时在每个样品上滴一滴牙膏浆（1：3）。表面硬度和TMR分析通过ANOVA/Tukey和t检验进行分析（p < 0.05）。通过分析表面硬度恢复百分比，S-PRG填充剂和高露洁®牙膏同样能够提高2-2.5倍的牙釉质矿化。然而，与安慰剂（1，050 ± 467% vol. μm）相比，S-PRG牙膏是唯一能够显著改善ΔΔZ（综合矿物质损失恢复率：1，489 ± 503% vol. μ m）的牙膏，而高露洁®与安慰剂没有差异。在ΔLD方面，未观察到组间差异。S-PRG填充剂和高露洁®牙膏显示出类似的使病变表面局部化的潜力。然而，S-PRG牙膏更好地恢复地下区域的矿物损失。
This study evaluated the remineralizing effect of a toothpaste containing surface pre-reacted glass-ionomer (S-PRG) filler on demineralized enamel in situ. For this, 180 bovine enamel samples were demineralized by using a microcosm biofilm model for 3 days. Thereafter, the samples were randomly signed to 15 healthy volunteers and to 3 cross-over in situ phases corresponding to the following treatments: (1) toothpaste containing 1,500 ppm F as NaMFP (positive control, Colgate®Cavity Protection), (2) toothpaste containing 5% S-PRG filler (Shofu®), and (3) placebo toothpaste (negative control prepared by Shofu®). Four demineralized enamel blocks were fixed into each palatal appliance per phase. The volunteers wore the appliances for 5 days and were trained to brush their teeth 2 times for 2 min a day, while one drop of the toothpaste’s slurry (1:3) was dripped on each sample for the same period. The surface hardness and TMR analyses were done and analyzed by ANOVA/Tukey and t test (p < 0.05). S-PRG filler and Colgate® toothpastes were equally able to improve 2–2.5× enamel remineralization by the analysis of % surface hardness recovery. However, S-PRG toothpaste was the only one able to significantly improve ΔΔZ (the integrated mineral loss recovery: 1,489 ± 503 %vol.μm) compared to placebo (1,050 ± 467 %vol.μm), while Colgate® did not differ from placebo. No differences were seen between the groups with respect to ΔLD. S-PRG filler and Colgate® toothpastes show similar potential to remineralize the lesion surface. However, S-PRG toothpaste is better to recover mineral loss at the subsurface area.
影响因子：
3.8
作者：
Tamura, Muneaki;Cueno, Marni E.;Imai, Kenichi
通讯作者：
Imai, Kenichi
表面预反应玻璃离子填料和洗出液的抗菌作用 – 迷你回顾
DOI：
--
发表时间：
2015
期刊：
Pharmaceutica Analytica Acta (in press)
影响因子：
--
作者：
Masahiro Yoneda;Nao Suzuki;Takao Hirofuji
通讯作者：
Takao Hirofuji
影响因子：
2.5
作者：
Shimazu, Kisaki;Oguchi, Riyo;Karibe, Hiroyuki
通讯作者：
Karibe, Hiroyuki