On the origin of cells and viruses: primordial virus world scenario.

On the origin of cells and viruses: primordial virus world scenario.
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DOI:
10.1111/j.1749-6632.2009.04992.x
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发表时间:
2009-10
影响因子:
5.2
通讯作者:
Koonin EV
Koonin EV
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Koonin EV

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有人提出,生物进化的前细胞阶段在含有病毒样遗传元件的多样化混合物的无机隔室网络中解开。这个进化阶段可能构成了最后一个普遍细胞祖先(LUCA),更恰当地说,它可以被称为最后一个普遍细胞祖先状态(LUCAS)。这样一种情景概括了J. B的思想。S.哈尔德在他1928年的经典散文中勾勒出。然而,与Halfman的时代不同,今天存在对这种情况的大量支持:古细菌和细菌中核心DNA复制系统组件之间缺乏同源性,古细菌和细菌中脂质生物合成的不同膜化学和酶,几种病毒标志基因在不同病毒群中的传播,以及现存的古细菌和细菌染色体似乎是由不同的较小复制子堆积而形成的。在细胞前进化的病毒模型下,细胞的关键成分起源于病毒样实体的成分。现存的两种细胞生命形式,古生菌和细菌,可能是独立地从卢卡斯出现的,沿着的,可能还有许多现在已经灭绝的形式。
It is proposed that the precellular stage of biological evolution unraveled within networks of inorganic compartments that harbored a diverse mix of virus‐like genetic elements. This stage of evolution might makes up the Last Universal Cellular Ancestor (LUCA) that more appropriately could be denoted Last Universal Cellular Ancestral State (LUCAS). Such a scenario recapitulates the ideas of J. B. S. Haldane sketched in his classic 1928 essay. However, unlike in Haldane's day, considerable support for this scenario exits today: lack of homology between core DNA replication system components in archaea and bacteria, distinct membrane chemistries and enzymes of lipid biosynthesis in archaea and bacteria, spread of several viral hallmark genes among diverse groups of viruses, and the extant archaeal and bacterial chromosomes appear to be shaped by accretion of diverse, smaller replicons. Under the viral model of precellular evolution, the key components of cells originated as components of virus‐like entities. The two surviving types of cellular life forms, archaea and bacteria, might have emerged from the LUCAS independently, along with, probably, numerous forms now extinct.
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