SARS-CoV-2 seroprevalence in a strictly-Orthodox Jewish community in the UK: A retrospective cohort study.
SARS-CoV-2 seroprevalence in a strictly-Orthodox Jewish community in the UK: A retrospective cohort study.
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DOI：
10.1016/j.lanepe.2021.100127
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Marks M
中科院分区：
文献类型：
--
作者：
Gaskell KM;Johnson M;Gould V;Hunt A;Stone NR;Waites W;Kasstan B;Chantler T;Lal S;Roberts CH;Goldblatt D;Eggo RM;Marks M
少数民族和宗教少数群体在全球范围内受到SARS-CoV-2的不成比例的影响。英国严格正统的犹太社区受到疫情的严重影响。这一群体与其他少数民族有着共同的特点，包括家庭规模较大、家庭拥挤率较高和社会经济相对贫困。我们研究了英国严格正统的犹太人口，以了解COVID-19在这个社区中的传播。我们在2020年10月底至12月初第三次全国封锁前进行了以家庭为重点的SARS-CoV-2横断面血清调查。随机选择的家庭完成了标准化问卷调查，并进行了SARS-CoV-2 IgG抗体的多重检测血清学检测。我们报告临床疾病和血清调查前的测试，血清阳性率分层的年龄和性别。我们使用随机效应模型来确定与感染和抗体滴度相关的因素。共招募了343户，包括1 759人。血清可用于1，242名参与者。SARS-CoV-2的总体血清阳性率为64.3%（95%CI 61.6-67.0%）。5岁以下儿童的血清阳性率最低，为27.6%，中学儿童上升到73.8%，成人上升到74%。自报告COVID-19症状以来，抗体滴度在有症状的个体中较高，并随着时间的推移而下降，其中核衣壳滴度的下降更为明显。在英国这个紧密团结的宗教少数群体中，我们报告了迄今为止世界上最高的SARS-CoV-2血清阳性率水平之一，这明显高于研究时伦敦报告的10%血清阳性率。在这种高感染力的背景下，所有年龄组都经历了高感染负担。迫切需要采取行动，减轻这一群体和其他少数群体的疾病负担。这项工作由UKRI和NIHR共同资助[COV 0335; MR/V027956/1]，由LSHTM校友COVID-19应对基金，HDR UK，MRC和Wellcome Trust捐赠。
Ethnic and religious minorities have been disproportionately affected by SARS-CoV-2 worldwide. The UK strictly-Orthodox Jewish community has been severely affected by the pandemic. This group shares characteristics with other ethnic minorities including larger family sizes, higher rates of household crowding and relative socioeconomic deprivation. We studied a UK strictly-Orthodox Jewish population to understand transmission of COVID-19 within this community. We performed a household-focused cross-sectional SARS-CoV-2 serosurvey between late-October and early December 2020 prior to the third national lockdown. Randomly-selected households completed a standardised questionnaire and underwent serological testing with a multiplex assay for SARS-CoV-2 IgG antibodies. We report clinical illness and testing before the serosurvey, seroprevalence stratified by age and sex. We used random-effects models to identify factors associated with infection and antibody titres. A total of 343 households, consisting of 1,759 individuals, were recruited. Serum was available for 1,242 participants. The overall seroprevalence for SARS-CoV-2 was 64.3% (95% CI 61.6-67.0%). The lowest seroprevalence was 27.6% in children under 5 years and rose to 73.8% in secondary school children and 74% in adults. Antibody titres were higher in symptomatic individuals and declined over time since reported COVID-19 symptoms, with the decline more marked for nucleocapsid titres. In this tight-knit religious minority population in the UK, we report one of the highest SARS-CoV-2 seroprevalence levels in the world to date, which was markedly higher than the reported 10% seroprevalence in London at the time of the study. In the context of this high force of infection, all age groups experienced a high burden of infection. Actions to reduce the burden of disease in this and other minority populations are urgently required. This work was jointly funded by UKRI and NIHR [COV0335; MR/V027956/1], a donation from the LSHTM Alumni COVID-19 response fund, HDR UK, the MRC and the Wellcome Trust.
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影响因子：
4.7
作者：
Cable, Noriko;Sacker, Amanda
通讯作者：
Sacker, Amanda
影响因子：
13.8
作者：
Zyskind I;Rosenberg AZ;Zimmerman J;Naiditch H;Glatt AE;Pinter A;Theel ES;Joyner MJ;Hill DA;Lieberman MR;Bigajer E;Stok D;Frank E;Silverberg JI
通讯作者：
Silverberg JI
DOI：
10.1016/s0140-6736(20)32465-x
发表时间：
2020-12-12
期刊：
Lancet (London, England)
影响因子：
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作者：
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DOI：
10.1093/cid/ciaa1091
发表时间：
2021-12-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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作者：
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影响因子：
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作者：
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