Differential trends in the rising incidence of endometrial cancer by type: data from a UK population-based registry from 1994 to 2006.
Differential trends in the rising incidence of endometrial cancer by type: data from a UK population-based registry from 1994 to 2006.
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DOI：
10.1038/bjc.2011.68
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发表时间：
2011-04-26
影响因子：
8.8
通讯作者：
Sundar, S.
中科院分区：
文献类型：
--
作者：
Evans, T.;Sany, O.;Pearmain, P.;Ganesan, R.;Blann, A.;Sundar, S.
子宫内膜癌是西方世界最常见的妇科癌症，自1993年以来，英国的发病率增加了40%以上。子宫内膜癌有两种类型：雌激素依赖性1型预后良好，非雌激素依赖性2型预后较差。子宫内膜癌增加的组织病理学分布尚不清楚。本研究调查了观察到的两种类型的发病率趋势、年龄、分期和社会经济分布的增加和生存结局。研究人员分析了1994年至2006年间在英国人口癌症登记处登记的6867名子宫内膜癌患者的数据。子宫内膜癌发病率的增加仅限于1型癌症，年龄标准化发病率（ASR）从1994年的12.0 / 10万（置信区间（CI） 10.7-13.2）显著增加到2006年的16.3 / 10万（CI 14.9-17.7）， P<0.001，而2型癌症的ASR从1994年的2.5 / 10万（CI 2.0-3.1）增加到2006年的2.2 / 10万（CI 1.7-2.7）， P< 0.05无统计学意义。1型癌症的增加在60-69岁年龄组（P<0.001）和70-79岁年龄组（P<0.001）最为显著，并且在社会经济五分位数中分布均匀。虽然1型癌症的预后有所改善，但2型癌症的1年生存率没有变化，从1994年的73.1%降至74.3%，P=0.089, 5年生存率从55.1%降至40.9%，P=0.001。子宫内膜癌发病率的增加仅限于1型癌症，在60-79岁年龄组和所有社会经济五分位数中最常见。2型癌症患者的生存率显著下降。迫切需要研究1型癌症的预防策略和改善2型癌症的治疗。
Endometrial cancer is the most common gynaecological cancer in the western world, the incidence increasing in the United Kingdom by over 40% since 1993. Two types of endometrial cancer exist – oestrogen-dependent type 1 with good prognosis and non-oestrogen-dependent type 2 with poor prognosis. The histopathological distribution of the increase in endometrial cancer is unknown. This study investigates the observed incidence trends of the two types, the age, stage, and socioeconomic distribution of this increase and survival outcome. Data were analysed from 6867 women with endometrial cancer registered between 1994 and 2006, at a UK population-based cancer registry. Increased endometrial cancer incidence is confined to type 1 cancers with a significant increase in age standardised incidence rate (ASR) from 12.0 per 100 000 (confidence interval (CI) 10.7–13.2) in 1994 to 16.3 per 100 000 (CI 14.9–17.7), P<0.001 in 2006, while ASR of type 2 cancer changed from 2.5 per 100 000 (CI 2.0–3.1) in 1994 to 2.2 per 100 000 (CI 1.7–2.7) in 2006, which was not statistically significant P>0.05. Increase in type 1 cancer is most marked in age groups 60–69 years (P<0.001) and 70–79 years (P<0.001) and distributed equally among socioeconomic quintiles. While outcome for type 1 cancer has improved, 1-year survival in type 2 cancer is unchanged from 73.1% in 1994 to 74.3%, P=0.089 and 5-year survival decreased from 55.1% to 40.9%, P=0.001. Increased incidence in endometrial cancer is confined to type 1 cancers, seen most in the 60–79 age groups and across all socioeconomic quintiles. Survival in type 2 cancer has decreased significantly. Urgent research is needed to investigate prevention strategies in type 1 and improve therapy in type 2 cancers.
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影响因子：
168.9
作者：
Renehan, Andrew G.;Tyson, Margaret;Zwahlen, Marcel
通讯作者：
Zwahlen, Marcel
DOI：
10.1016/j.jsbmb.2007.09.020
发表时间：
2008-02-01
影响因子：
4.1
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
8.4
作者：
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通讯作者：
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影响因子：
2.6
作者：
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通讯作者：
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