Corticotropin releasing hormone receptor 2 (CRHR-2) gene is associated with decreased risk and severity of posttraumatic stress disorder in women.
Corticotropin releasing hormone receptor 2 (CRHR-2) gene is associated with decreased risk and severity of posttraumatic stress disorder in women.
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DOI：
10.1002/da.22176
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发表时间：
2013-12
影响因子：
7.4
通讯作者：
Miller, Mark W.
中科院分区：
文献类型：
--
作者：
Wolf, Erika J.;Mitchell, Karen S.;Logue, Mark W.;Baldwin, Clinton T.;Reardon, Annemarie F.;Humphries, Donald E.;Miller, Mark W.
促肾上腺皮质激素释放激素(CRH)系统与多种焦虑和情绪相关的症状和障碍有关。CRH受体-2(CRHR-2)在减弱对应激性生活事件和创伤的生物反应中发挥作用，使CRHR-2基因成为研究创伤后应激障碍(PTSD)的有力候选基因。样本是491名创伤暴露的非西班牙裔白人退伍军人和他们的同居亲密伴侣，通过结构化访谈对终生DSM-IV创伤后应激障碍进行评估；略高于60%的人符合这种疾病的标准。从一组250万个标记中获得的CRHR-2及其附近的31个单核苷酸多态(SNPs)分别在整个样本和男性和女性中被测试与创伤后应激障碍的诊断和症状严重程度的相关性。在全样本中，10个SNP显示名义上与PTSD相关的显著证据，两个SNP(rs8192496和rs2190242)在基于排列的多重测试校正后显著相关(未校正的PS=.0004和.0005，优势比分别为.60和.58)。按性别分层的分析显示，这种影响是针对女性的，她们占样本的35%(未校正的PS=.0003和.0002，优势比分别为.41和.35)。另外两个SNP(rs2267715和rs2284218)也显示出与女性创伤后应激障碍显著相关(两个SNP的未校正PS=.001，优势比均为.48)。结果表明，CRHR-2变异体可能通过减弱压力反应和减轻疾病症状而影响女性患创伤后应激障碍的风险。
The corticotropin releasing hormone (CRH) system has been implicated in a variety of anxiety and mood-based symptoms and disorders. CRH receptor-2 (CRHR-2) plays a role in attenuating biological responses to stressful life events and trauma, making the CRHR-2 gene a strong candidate to study in relationship to posttraumatic stress disorder (PTSD). The sample was 491 trauma-exposed white non-Hispanic veterans and their cohabitating intimate partners assessed via structured interview for lifetime DSM-IV PTSD; just over 60% met criteria for the disorder. Thirty-one single nucleotide polymorphisms (SNPs) in and near CRHR-2, obtained from an array of 2.5 million markers, were tested for association with PTSD diagnosis and symptom severity in the whole sample and in men and women separately. Ten SNPs showed nominally significant evidence of association with PTSD in the full sample and two SNPs (rs8192496 and rs2190242) were significant after permutation-based multiple testing correction (uncorrected ps = .0004 and .0005, odds ratios = .60 and .58, respectively). Analyses stratified by sex revealed that the effect was specific to women, who comprised 35% of the sample (uncorrected ps = .0003 and .0002, odds ratios = .41 and .35, respectively). Two additional SNPs (rs2267715 and rs2284218) also showed significant association with PTSD in women (both uncorrected ps = .001, both odds ratios = .48). Results suggest that CRHR-2 variants may affect risk for PTSD in women by attenuating the stress response and reducing symptoms of the disorder.
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DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
5.3
作者：
Deussing, Jan M.;Breu, Johannes;Wurst, Wolfgang
通讯作者：
Wurst, Wolfgang
影响因子：
3.5
作者：
Bale, TL
通讯作者：
Bale, TL
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
6.7
作者：
Cornelis, Marilyn C.;Nugent, Nicole R.;Amstadter, Ananda B.;Koenen, Karestan C.
通讯作者：
Koenen, Karestan C.