Fgf10/Fgfr2b Signaling Orchestrates the Symphony of Molecular, Cellular, and Physical Processes Required for Harmonious Airway Branching Morphogenesis.
Fgf10/Fgfr2b Signaling Orchestrates the Symphony of Molecular, Cellular, and Physical Processes Required for Harmonious Airway Branching Morphogenesis.
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DOI：
10.3389/fcell.2020.620667
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发表时间：
2020
影响因子：
5.5
通讯作者：
Bellusci S
中科院分区：
文献类型：
--
作者：
Jones MR;Chong L;Bellusci S
气道分支的形态发生取决于多种生物和物理因素在不同空间尺度上相互联系的复杂协调。控制气道分支的关键调控途径之一是成纤维细胞生长因子10 （Fgf10）通过其上皮成纤维细胞生长因子受体2b （Fgfr2b）发出信号。关于分支形态发生的分子机制，特别是与Fgf10/Fgfr2b信号通路相关的机制，已经发表了大量的综述。然而，对分支中涉及的所有主要生物和物理因素，分支运作的不同尺度，以及Fgf10/Fgfr2b在其中的已知作用的全面回顾是缺失的。在这篇综述中，我们试图从广义的角度总结现有的关于气道分支形态发生的文献。我们专注于生物物理和机械力直接塑造上皮芽起始，分支延伸和分支尖端分叉。然后，我们将焦点转移到更被动的方式，通过细胞外基质重塑和其他肺乔枝网络（脉管系统和神经）的影响，分支进行。最后，我们简要讨论了气道分支的计算建模工作。自始至终，我们在讨论的每一点上都强调Fgfr2b信号的已知或推测作用。我们的目标是促进对分支形态发生的理解，以捕获该现象的多标量生物学和物理性质，并采用跨学科方法进行研究。
Airway branching morphogenesis depends on the intricate orchestration of numerous biological and physical factors connected across different spatial scales. One of the key regulatory pathways controlling airway branching is fibroblast growth factor 10 (Fgf10) signaling via its epithelial fibroblast growth factor receptor 2b (Fgfr2b). Fine reviews have been published on the molecular mechanisms, in general, involved in branching morphogenesis, including those mechanisms, in particular, connected to Fgf10/Fgfr2b signaling. However, a comprehensive review looking at all the major biological and physical factors involved in branching, at the different scales at which branching operates, and the known role of Fgf10/Fgfr2b therein, is missing. In the current review, we attempt to summarize the existing literature on airway branching morphogenesis by taking a broad approach. We focus on the biophysical and mechanical forces directly shaping epithelial bud initiation, branch elongation, and branch tip bifurcation. We then shift focus to more passive means by which branching proceeds, via extracellular matrix remodeling and the influence of the other pulmonary arborized networks: the vasculature and nerves. We end the review by briefly discussing work in computational modeling of airway branching. Throughout, we emphasize the known or speculative effects of Fgfr2b signaling at each point of discussion. It is our aim to promote an understanding of branching morphogenesis that captures the multi-scalar biological and physical nature of the phenomenon, and the interdisciplinary approach to its study.
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DOI：
10.1002/path.5188
发表时间：
2019-03
期刊：
The Journal of pathology
影响因子：
--
作者：
Danopoulos S;Thornton ME;Grubbs BH;Frey MR;Warburton D;Bellusci S;Al Alam D
通讯作者：
Al Alam D
影响因子：
12.5
作者：
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通讯作者：
Manning, M. Lisa
影响因子：
4.4
作者：
Bokka, Kishore K.;Jesudason, Edwin C.;Lubkin, Sharon R.
通讯作者：
Lubkin, Sharon R.
影响因子：
2
作者：
Bokka, Kishore K.;Jesudason, Edwin C.;Lubkin, Sharon R.
通讯作者：
Lubkin, Sharon R.
DOI：
10.1165/rcmb.2007-0246oc
发表时间：
2008-03-01
影响因子：
6.4
作者：
Burns, Alan J.;Thapar, Nikhil;Barlow, Amanda J.
通讯作者：
Barlow, Amanda J.