Gut microbiome differences between amyotrophic lateral sclerosis patients and spouse controls.
Gut microbiome differences between amyotrophic lateral sclerosis patients and spouse controls.
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DOI：
10.1080/21678421.2021.1904994
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发表时间：
2022-02
影响因子：
2.8
通讯作者：
Glass, Jonathan D.
中科院分区：
文献类型：
--
作者：
Hertzberg, Vicki S.;Singh, Harinder;Fournier, Christina N.;Moustafa, Ahmed;Polak, Meraida;Kuelbs, Claire A.;Torralba, Manolito G.;Tansey, Malu G.;Nelson, Karen E.;Glass, Jonathan D.
关键词：
肌萎缩侧索硬化症（ALS）是一种进行性神经退行性疾病，无法治愈，最终致命。患者可用的治疗选择很少。在这项研究中，我们探讨了与 ALS 相关的微生物组组成的差异。我们将 ALS 患者 (n=10) 与其配偶 (n=10) 的肠道微生物组和炎症标志物谱进行了比较。通过 16S rRNA 基因测序确定肠道微生物组概况。 ALS 患者的肠道微生物群落更加多样化，并且缺乏普氏菌属。与他们的配偶相比。相比之下，从与患者群体相同的地理区域招募的健康夫妇（n = 10对异性夫妇）没有表现出这些差异。 ALS 患者及其配偶的粪便和血浆炎症标志物相似。对微生物酶的预测分析表明，ALS 患者的多种代谢途径的活性降低，包括碳代谢、丁酸代谢以及涉及组氨酸激酶和反应调节剂的系统。与配偶对照组相比，ALS 患者的肠道微生物群落表现出差异。我们的研究结果表明，改变肠道微生物组，例如通过改善普雷沃氏菌属。缺乏和/或改变丁酸代谢可能对 ALS 治疗具有转化价值。
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that is incurable and ultimately fatal. Few therapeutic options are available to patients. In this study, we explored differences in microbiome composition associated with ALS. We compared the gut microbiome and inflammatory marker profiles of ALS patients (n=10) to those of their spouses (n=10). Gut microbiome profiles were determined by 16S rRNA gene sequencing. The gut microbial communities of the ALS patients were more diverse and were deficient in Prevotella spp. compared with those of their spouses. In contrast, healthy couples (n=10 couples of the opposite sex) recruited from the same geographic region as the patient population did not exhibit these differences. Stool and plasma inflammatory markers were similar between ALS patients and their spouses. Predictive analysis of microbial enzymes revealed that ALS patients had decreased activity in several metabolic pathways, including carbon metabolism, butyrate metabolism, and systems involving histidine kinase and response regulators. ALS patients exhibit differences in their gut microbial communities compared with spouse controls. Our findings suggest that modifying the gut microbiome, such as via amelioration of Prevotella spp. deficiency, and/or altering butyrate metabolism may have translational value for ALS treatment.
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使用高通量测序评估肌萎缩侧索硬化症的微生物多样性
影响因子：
5.2
作者：
Fang X;Wang X;Yang S;Meng F;Wang X;Wei H;Chen T
通讯作者：
Chen T
影响因子：
16.6
作者：
Jangi S;Gandhi R;Cox LM;Li N;von Glehn F;Yan R;Patel B;Mazzola MA;Liu S;Glanz BL;Cook S;Tankou S;Stuart F;Melo K;Nejad P;Smith K;Topçuolu BD;Holden J;Kivisäkk P;Chitnis T;De Jager PL;Quintana FJ;Gerber GK;Bry L;Weiner HL
通讯作者：
Weiner HL
DOI：
10.1002/mds.27326
发表时间：
2018-05
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Houser MC;Chang J;Factor SA;Molho ES;Zabetian CP;Hill-Burns EM;Payami H;Hertzberg VS;Tansey MG
通讯作者：
Tansey MG
影响因子：
5.8
作者：
Edgar, Robert C.
通讯作者：
Edgar, Robert C.
影响因子：
64.8
作者：
Blacher, Eran;Bashiardes, Stavros;Elinav, Eran
通讯作者：
Elinav, Eran