Vitamin D Receptor Fok I Polymorphism and Risk of Hepatocellular Carcinoma in HBV-Infected Patients
Vitamin D Receptor Fok I Polymorphism and Risk of Hepatocellular Carcinoma in HBV-Infected Patients
复制标题
维生素 D 受体 Fok I 多态性与 HBV 感染患者发生肝细胞癌的风险
DOI：
10.5812/hepatmon.85075
复制
发表时间：
2019-01
影响因子：
0.6
通讯作者：
Ma Yi
中科院分区：
文献类型：
--
作者：
Rao Jiawei;Wu Xukun;Zhou Xiaozhuan;Deng Ronghai;Ma Yi
背景：我们进行了一项荟萃分析，以评估维生素D受体（VDR）多态性在乙型肝炎病毒（HBV）感染患者发生肝细胞癌（HCC）风险中的作用。目的：研究HCC的潜在病因，为肝癌的预防、机制和治疗提供新的思路。近年来，VDR多态性与hbv相关性HCC发病风险的关系越来越受到关注，但尚未有明确结论。检索数据来源：PubMed/Medline、EMBASE、Cochrane图书馆、中国国家知识基础设施、中国技术期刊VIP数据库、万方数据、SINOMED数据库，检索截止至2018年8月。纳入报告VDR多态性和hbv相关HCC风险的研究，并采用纽卡斯尔-渥太华量表（NOS）评估质量。计算优势比（OR）和95%置信区间（CI），比较不同基因型（如FF、FF、F、F、FF） HCC风险的汇总数据。结果：3项病例对照研究共纳入728例HBV相关HCC病例和920例HBV对照。当比较与乙型肝炎病毒有关的肝癌病例与乙肝病毒控制,我们的数据显示,所有基因型的)我多态性显著增加肝癌的风险在整个人口(ff vs ff: = 1.816, 95% CI = 1.161 - 2.841, P = 0.0009; ff vs ff: = 1.315, 95% CI = 1.037 - 1.667, P = 0.024; ff / ff和ff或= 1.504,95% CI = 1.206 - 1.876, P < 0.001; ff和ff / ff: = 1.591, 95% CI = 1.270 - 1.992, P < 0.001; ff和ff: = 1.435, 95% CI = 1.127 - 1.827, P = 0.003;f vs. f: OR = 1.375, 95% CI = 1.075 - 1.759)。结论：我们的分析结果提示Fok I多态性“f”等位基因可能是hbv感染患者发生HCC的危险因素，并可作为筛查hbv感染患者HCC的预测因素。然而，需要更准确的分析和更大规模的研究。
Context: We conducted a meta-analysis to evaluate the role of the vitamin D receptor (VDR) polymorphism in the risk of hepatocellular carcinoma (HCC) in patients infected with hepatitis B virus (HBV). Objective: To develop new preventions, mechanisms, and therapies for HCC, it is important to investigate the underlying causes of HCC. Recently, there has been increasing attention to the relationship between VDR polymorphism and the risk of HBV-related HCC, but no specific conclusion has been made. Data Sources: PubMed/Medline, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, Wanfang Data, and SINOMED databases were searched until August 2018. Studies reporting VDR polymorphism and HBV-related HCC risks were included and the quality was assessed by Newcastle-Ottawa scale (NOS). Odds ratio (OR) and 95% confidence interval (CI) were calculated to compare the pooled data between HCC risks and different genotypes, such as FF, Ff, F, f, and ff, with each other. Results: Three case-control studies with totally 728 HBV-related HCC cases and 920 HBV controls were included. When comparing HBV-related HCC cases with HBV controls, our data showed that all genotypes of Fok I polymorphism significantly increased the risk of HCC in the overall population (ff vs. FF: OR = 1.816, 95% CI = 1.161 - 2.841, P = 0.0009; Ff vs. FF: OR = 1.315, 95% CI = 1.037 - 1.667, P = 0.024; ff/Ff vs. FF, OR = 1.504, 95% CI = 1.206 - 1.876, P < 0.001; ff vs. FF/Ff: OR = 1.591, 95% CI = 1.270 - 1.992, P < 0.001; ff vs. Ff: OR = 1.435, 95% CI = 1.127 - 1.827, P = 0.003; f vs. F: OR = 1.375, 95% CI = 1.075 - 1.759). Conclusion: The results of our analysis suggest the “f” allele of Fok I polymorphism might be a risk factor for HCC in HBV-infected patients and it could be a predictive factor to screen HCC in HBV-infected patients. However, more accurate analyses and larger studies are needed.
登录
查看更多内容
影响因子：
1.4
作者：
G. Hager;M. Formanek;C. Gedlicka;D. Thurnher;B. Knerer;J. Kornfehl
通讯作者：
G. Hager;M. Formanek;C. Gedlicka;D. Thurnher;B. Knerer;J. Kornfehl
维生素D模拟seocalcitol的II期研究对无法手术的肝细胞癌患者。
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
6.2
作者：
Sarkissyan, Marianna;Wu, Yanyuan;Chen, Zujian;Mishra, Dhruva K.;Sarkissyan, Suren;Giannikopoulos, Ioannis;Vadgama, Jaydutt V.
通讯作者：
Vadgama, Jaydutt V.
DOI：
--
发表时间：
2013
期刊：
--
影响因子：
--
作者：
J. Ferlay;I. Soerjomataram;M. Ervik;R. Dikshit;S. Eser;C. Mathers
通讯作者：
J. Ferlay;I. Soerjomataram;M. Ervik;R. Dikshit;S. Eser;C. Mathers
影响因子：
4.1
作者：
G. Whitfield;L. S. Remus;P. Jurutka;H. Zitzer;A. K. Oza;H. Dang;C. Haussler;M. Galligan;Michelle L. T
通讯作者：
G. Whitfield;L. S. Remus;P. Jurutka;H. Zitzer;A. K. Oza;H. Dang;C. Haussler;M. Galligan;Michelle L. T