Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants.
Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants.
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DOI：
10.1002/cncr.28565
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发表时间：
2014-05-01
期刊：
影响因子：
6.2
通讯作者：
Vadgama, Jaydutt V.
中科院分区：
文献类型：
--
作者：
Sarkissyan, Marianna;Wu, Yanyuan;Chen, Zujian;Mishra, Dhruva K.;Sarkissyan, Suren;Giannikopoulos, Ioannis;Vadgama, Jaydutt V.
维生素D在癌症肿瘤发生中起作用，并通过维生素D受体（VDR）起作用。虽然非裔美国人的血清维生素D水平最低，但补充维生素D并没有显著改善癌症。VDR基因多态性可能起作用。在代表性不足的种族群体中，关于VDR基因多态性和结直肠癌（CRC）的信息缺乏。本研究探讨了VDR单核苷酸多态性是否与主要为非洲裔美国人和西班牙裔研究参与者的CRC相关。从378名参与者收集血液，其中78名结肠直肠癌患者（病例），230名无息肉的非癌症受试者（对照组w/o息肉）和70名有息肉的非癌症受试者（对照组w/息肉）。采用PCR-RFLP方法检测VDR基因FokI、BsmI、TaqI、ApaI 4个多态性位点。与无息肉的对照组相比，VDR-Fok 1 FF基因型与CRC病例显著相关（OR=2.9; P=0.036）。总体研究人群中最常见的VDR-Fok 1基因型是FF基因型（46%）。然而，按种族细分后，FF在非裔美国人参与者中最常见（61%），Ff在西班牙裔/拉丁裔参与者中最常见（49%）。在多因素模型中，VDR基因多态性与结直肠癌的发生无显著相关性（P>0.05）。VDR的其他3个多态性变异体（BsmI、TaqI和ApaI）与结直肠癌无关。这项研究表明，VDR-FokI SNPs的遗传变异可能会影响CRC风险，特别是在非洲裔美国人队列中。
Vitamin D plays a role in cancer tumorogenesis and acts through the vitamin D receptor (VDR). Although African Americans have the lowest levels of vitamin D serum levels, supplementation has not yielded significant improvement in cancer. Gene polymorphisms in VDR may play a role. There is dearth of information on VDR gene polymorphisms and colorectal cancer (CRC) among underrepresented ethnic groups. This study examines whether VDR SNPs, single-nucleotide-gene-polymorphisms, are associated with CRC in predominately African American and Hispanic study participants. Blood was collected from 378 participants, with 78 colorectal-cancer patients (Cases), 230 non-cancer subjects with no polyps (Controls w/o polyps), and 70 non-cancer subjects with polyps (Controls w/polyp). The four polymorphic SNPs in VDR (FokI, BsmI, TaqI, ApaI) were assessed using the PCR-RFLP method. There was significant association of the VDR-Fok1 FF genotype with CRC Cases (OR=2.9; P=0.036) when compared with Controls w/o polyps. The most common VDR-Fok1 genotype in the overall study population was the FF genotype (46%). However, upon breakdown by ethnicity, the FF was the most common in African American participants (61%), and the Ff was most common in Hispanic/Latino participants (49%). When the association was assessed in a multivariate model, there was no significant association with any VDR polymorphism and CRC Cases (P>0.05). The other three polymorphic variants of VDR (BsmI, TaqI and ApaI) were not associated with CRC. This study suggests that genetic variation of the VDR-FokI SNPs may influence CRC risk, particularly in African American cohorts.
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影响因子：
4
作者：
Gutierrez, O. M.;Farwell, W. R.;Kermah, D.;Taylor, E. N.
通讯作者：
Taylor, E. N.
DOI：
10.1158/1940-6207.capr-08-0157
发表时间：
2009-03
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Fedirko V;Bostick RM;Flanders WD;Long Q;Shaukat A;Rutherford RE;Daniel CR;Cohen V;Dash C
通讯作者：
Dash C
影响因子：
--
作者：
Martins, David;Wolf, Myles;Norris, Keith
通讯作者：
Norris, Keith
DOI：
10.1093/jnci/djg110
发表时间：
2003-12-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Grau, MV;Baron, JA;Heber, D
通讯作者：
Heber, D
DOI：
10.1158/1940-6207.capr-12-0292
发表时间：
2012-10
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Ahearn TU;Shaukat A;Flanders WD;Rutherford RE;Bostick RM
通讯作者：
Bostick RM