A global view of the human post-translational modification landscape.
A global view of the human post-translational modification landscape.
复制标题
DOI：
10.1042/bcj20220251
复制
发表时间：
2023-08-30
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
翻译后修饰（PTM）提供了对刺激的快速反应，微调代谢和基因表达并维持稳态。在过去的二十年中，质谱技术的进步显着扩大了生物学中已知的PTM列表，随着仪器的不断改进，这个列表肯定会增加。虽然已经详细研究了许多PTM（例如磷酸化，乙酰化），但绝大多数缺乏明确的调控机制和对细胞命运的影响。在这篇综述中，我们将重点介绍PTM研究领域，因为它目前的立场，讨论的机制，决定网站的特异性，分析方法，其检测和研究，以及化学工具，可以利用来定义PTM监管。此外，我们还将重点介绍发现和验证新型PTM所需的方法。最后，这篇综述将为那些对PTM生物学感兴趣的人提供一个起点，提供一个全面的PTM列表以及关于它们的调节和代谢起源的已知信息。
Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning metabolism and gene expression and maintain homeostasis. Advances in mass spectrometry over the past two decades have significantly expanded the list of known PTMs in biology and as instrumentation continues to improve, this list will surely grow. While many PTMs have been studied in detail (e.g. phosphorylation, acetylation), the vast majority lack defined mechanisms for their regulation and impact on cell fate. In this review, we will highlight the field of PTM research as it currently stands, discussing the mechanisms that dictate site specificity, analytical methods for their detection and study, and the chemical tools that can be leveraged to define PTM regulation. In addition, we will highlight the approaches needed to discover and validate novel PTMs. Lastly, this review will provide a starting point for those interested in PTM biology, providing a comprehensive list of PTMs and what is known regarding their regulation and metabolic origins.
影响因子：
3.4
作者：
Zhang, Kai;Chen, Yue;Zhang, Zhihong;Tao, Shengce;Zhu, Heng;Zhao, Yingming
通讯作者：
Zhao, Yingming
影响因子：
3.4
作者：
Arsenault, Patrick R.;Heaton-Johnson, Katherine J.;Li, Lin-sheng;Song, Daisheng;Ferreira, Vinicius S.;Patel, Nish;Master, Stephen R.;Lee, Frank S.
通讯作者：
Lee, Frank S.
对1,000个细胞的组蛋白修饰的靶向检测和定量。
影响因子：
3.7
作者：
Abshiru NA;Sikora JW;Camarillo JM;Morris JA;Compton PD;Lee T;Neelamraju Y;Haddox S;Sheridan C;Carroll M;Cripe LD;Tallman MS;Paietta EM;Melnick AM;Thomas PM;Garrett-Bakelman FE;Kelleher NL
通讯作者：
Kelleher NL