A global chromatin compaction pathway that represses germline gene expression during starvation.
A global chromatin compaction pathway that represses germline gene expression during starvation.
复制标题
DOI：
10.1083/jcb.202009197
复制
发表时间：
2021-09-06
期刊：
影响因子：
--
通讯作者：
Michael WM
中科院分区：
文献类型：
--
作者：
Belew MD;Chien E;Wong M;Michael WM
Belew等报道C.如果胚胎在没有营养的情况下孵化，线虫的原始生殖细胞会受到转录抑制。他们还描述了一种新的途径，其中凝聚素II和TOP-2调节异染色质，以压缩种系基因组，从而全面抑制转录。虽然人们对单个基因如何控制转录知道得很多，但对细胞如何在全基因组水平上调节基因表达却知之甚少。在这里，我们确定了一个分子途径，在C。线虫的一种生殖细胞，它控制着对营养压力的全面反应。我们报告说，当胚胎孵化成L1幼虫，他们感觉到他们的环境的营养状况，如果食物是不可用的，他们抑制基因表达通过全球染色质致密化（GCC）途径。GCC由能量敏感激酶AMPK触发，并由一种新的机制介导，该机制涉及异染色质组装上游的拓扑异构酶II/凝聚素II轴。当GCC途径失活时，转录在饥饿期间持续存在。这些结果定义了一种新的全基因组转录控制模式。
Belew et al. report that C. elegans primordial germ cells become transcriptionally repressed if embryos hatch without nutrients. They also describe a novel pathway whereby condensin II and TOP-2 regulate heterochromatin to compact the germline genome to globally repress transcription. While much is known about how transcription is controlled at individual genes, comparatively little is known about how cells regulate gene expression on a genome-wide level. Here, we identify a molecular pathway in the C. elegans germline that controls transcription globally in response to nutritional stress. We report that when embryos hatch into L1 larvae, they sense the nutritional status of their environment, and if food is unavailable, they repress gene expression via a global chromatin compaction (GCC) pathway. GCC is triggered by the energy-sensing kinase AMPK and is mediated by a novel mechanism that involves the topoisomerase II/condensin II axis acting upstream of heterochromatin assembly. When the GCC pathway is inactivated, then transcription persists during starvation. These results define a new mode of whole-genome control of transcription.
登录
查看更多内容
影响因子：
11.8
作者：
Percharde M;Bulut-Karslioglu A;Ramalho-Santos M
通讯作者：
Ramalho-Santos M
影响因子：
64.5
作者：
Towbin, Benjamin D.;Gonzalez-Aguilera, Cristina;Gasser, Susan M.
通讯作者：
Gasser, Susan M.
DOI：
10.1073/pnas.1616171114
发表时间：
2017-03-28
影响因子：
11.1
作者：
Demoinet, Emilie;Li, Shaolin;Roy, Richard
通讯作者：
Roy, Richard
影响因子：
64.5
作者：
Gonzalez-Sandoval, Adriana;Towbin, Benjamin D.;Gasser, Susan M.
通讯作者：
Gasser, Susan M.
影响因子：
4.6
作者：
Mainpal, Rana;Nance, Jeremy;Yanowitz, Judith L.
通讯作者：
Yanowitz, Judith L.