Organochlorines in Swedish women: determinants of serum concentrations.
Organochlorines in Swedish women: determinants of serum concentrations.
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DOI：
10.1289/ehp.5456
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发表时间：
2003-03
影响因子：
10.4
通讯作者：
Weiderpass E
中科院分区：
文献类型：
--
作者：
Glynn AW;Granath F;Aune M;Atuma S;Darnerud PO;Bjerselius R;Vainio H;Weiderpass E
我们研究了205名瑞典女性（54-75岁）的生活方式/医疗因素与7种多氯联苯（PCB）同系物和5种氯化农药/代谢物的血脂调整血清浓度之间的关系。血清浓度与年龄、体重指数、体重变化、糖尿病、脂肪鱼消费和居住地显著相关。研究结果表明，当生活方式/医疗因素与血清浓度和疾病相关时，可能会混淆流行病学研究的结果。此外，疾病本身也可能影响某些有机氯的血清浓度，最近的体重变化与某些多氯联苯同系物、对二氯二苯二氯乙烯和六氯苯的血清浓度之间的负相关以及糖尿病与六氯苯浓度之间的正相关就表明了这一点。年龄是唯一的决定因素，表现出一致的所有化合物的研究（积极），否则协会与单一的决定因素之间的化合物，甚至在PCB组。这表明，在流行病学研究中，所研究的有机氯不应被视为一组同质的化合物。
We studied associations between lifestyle/medical factors and lipid-adjusted serum concentrations of seven polychlorinated biphenyl (PCB) congeners and five chlorinated pesticides/metabolites among 205 Swedish women (54-75 years old). Serum concentrations were significantly associated with age, body mass index, body weight change, diabetes mellitus, consumption of fatty fish, and place of residence. The findings suggest that lifestyle/medical factors may confound results in epidemiologic studies when they are related to both serum concentrations and disease. Moreover, disease itself may influence serum concentrations of some organochlorines, as indicated by the negative associations between recent weight change and serum concentrations of some PCB congeners, p,p -dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) and the positive association between diabetes mellitus and HCB concentrations. Age was the only determinant that showed a consistent association with all compounds studied (positive); otherwise associations with single determinants varied among compounds even within the PCB group. This shows that the studied organochlorines should not be treated as a homogeneous group of compounds in epidemiologic studies.
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影响因子：
10.4
作者：
Laden, F;Neas, LM;Hunter, DJ
通讯作者：
Hunter, DJ
影响因子：
2.3
作者：
Dorgan, JF;Brock, JW;Taylor, PR
通讯作者：
Taylor, PR
影响因子：
10.3
作者：
Laden, F;Collman, G;Hunter, DJ
通讯作者：
Hunter, DJ
影响因子：
2.3
作者：
Hoyer, AP;Jorgensen, T;Hartvig, HB
通讯作者：
Hartvig, HB
DOI：
10.1007/s002449900193
发表时间：
1997-04-01
影响因子：
4
作者：
Grimvall, E;Rylander, L;Ostman, C
通讯作者：
Ostman, C