Intratumoral delivery of an interferon gamma retrovirus-producing cells inhibits growth of a murine melanoma by a non-immune mechanism.
Intratumoral delivery of an interferon gamma retrovirus-producing cells inhibits growth of a murine melanoma by a non-immune mechanism.
复制标题
瘤内递送产生干扰素γ逆转录病毒的细胞通过非免疫机制抑制小鼠黑色素瘤的生长。
DOI：
10.1016/s0304-3835(01)00612-7
复制
发表时间：
2001
期刊：
影响因子：
9.7
通讯作者：
Thomas-Tikhonenko,A
中科院分区：
文献类型：
--
作者：
Yu,D;Thomas-Tikhonenko,A
Interferon gamma (IFNγ) is a potent inhibitor of cell growth effective against a wide range of tumor-derived cell lines. We cloned murine IFNγ cDNA into a retroviral vector and created a packaging cell line (Am-gamma) producing this IFNγ-encoding retrovirus. In a pilot experiment, admixing and co-injection of equal numbers of retrovirus-producing and target B16 melanoma cells led to high rates of infection and strong suppression of neoplastic growth. This effect was observed in the absence of measurable systemic production of IFNγ and could be reproduced in animals lacking cytotoxic immune responses. Tumor angiogenesis was unaffected and no increase in apoptosis was apparent; however, mitotic indices were greatly reduced in Am-gamma-containing abortive tumors. We thus concluded that IFNγ directly affects proliferation of B16 cells. Indeed, exposure of B16 cells to IFNγ in vitro inhibits cell division, as measured by a thymidine incorporation assay. Most importantly, repeated intratumoral injections of Am-gamma stunted growth of established B16 melanomas in 75% of treated animals. Thus, this approach can serve as a prototype for new anti-cancer modalities.
登录
查看更多内容
影响因子：
15.3
作者：
RESTIFO, NP;SPIESS, PJ;KARP, SE;MULE, JJ;ROSENBERG, SA
通讯作者：
ROSENBERG, SA
经 γ-IFN 处理的 B16-F10.9 黑色素瘤细胞免疫可防止母体肿瘤的转移性扩散
DOI：
--
发表时间：
1991
期刊：
International journal of cancer. Supplement = Journal international du cancer. Supplement
影响因子：
--
作者：
A. Porgador;Baruch Brenner;E. Vadai;M. Feldman;L. Eisenbach
通讯作者：
L. Eisenbach
影响因子：
4.4
作者：
J. Klostergaard;M. Leroux;M. Hung
通讯作者：
M. Hung
通过局部瘤内注射干扰素γ逆转录病毒载体产生全身抗肿瘤反应。
影响因子：
4.2
作者：
L. Karavodin;J. Robbins;K. Chong;D. Hsu;C. Ibañez;S. Mento;D. Jolly;T. Fong
通讯作者：
T. Fong
影响因子：
25.7
作者：
Gandhi CR
通讯作者：
Gandhi CR