A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis
A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis
复制标题
蛋白质组分析证实全身性载脂蛋白 A-IV 相关淀粉样变性
DOI：
10.1007/s00428-021-03073-x
复制
发表时间：
2021
期刊：
影响因子：
3.5
通讯作者：
Osanai Makoto
中科院分区：
文献类型：
--
作者：
Murakami Taro;Takasawa Akira;Moriki Asako;Igaki Yusuke;Ikeda Hiroshi;Murase Kazuyuki;Takada Kohichi;Magara Kazufumi;Aoyama Tomoyuki;Ono Yusuke;Kyuno Daisuke;Takasawa Kumi;Murata Masaki;Osanai Makoto
淀粉样变性是由某些蛋白质的细胞外沉积引起的。迄今为止，在人类中已经鉴定出36种蛋白质为淀粉样蛋白。虽然确定淀粉样蛋白的类型对淀粉样变性患者的治疗选择非常重要，但从淀粉样沉积组织中鉴定特定的蛋白质可能是困难的。载脂蛋白A-IV是一种淀粉样蛋白相关蛋白，但载脂蛋白A-IV淀粉样变性的报道很少。在这里，我们报告一例系统性载脂蛋白A-IV相关淀粉样变性，证实了蛋白质组分析，使用福尔马林固定石蜡包埋组织和免疫组化技术。
Amyloidosis is induced by extracellular deposition of certain proteins. Thirty-six proteins have so far been identified as amyloidogenic proteins in humans. Although it is very important to determine the specific amyloid protein type for the choice of therapy for amyloidosis patient, it might be difficult to identify specific proteins from amyloid-deposited tissue. Apolipoprotein A-IV is known as an amyloid-associated protein, but there have been few reports of apolipoprotein A-IV amyloidosis. Here we report a case of systemic apolipoprotein A-IV-associated amyloidosis that was confirmed by proteome analysis using formalin-fixed paraffin-embedded tissue and an immunohistochemical technique.
影响因子：
19.6
作者：
Sethi, Sanjeev;Theis, Jason D.;Dogan, Ahmet
通讯作者：
Dogan, Ahmet
通过基于质谱的蛋白质组学分析诊断与载脂蛋白 A-IV 沉积相关的心脏淀粉样变性
影响因子：
--
作者：
Elisabete Martins;J. Urbano;S. Leite;Adriana Pinto;Raquel Garcia;Rui Bergantim;P. Rodrigues;P. Costa;Hugo Osório;I. Tavares
通讯作者：
I. Tavares
影响因子：
19.6
作者：
Dasari, Surendra;Amin, Md. Shahrier;Sethi, Sanjeev
通讯作者：
Sethi, Sanjeev