Mechanisms of sepsis-induced immunosuppression and immunological modification therapies for sepsis.
Mechanisms of sepsis-induced immunosuppression and immunological modification therapies for sepsis.
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DOI：
10.1002/ags3.12194
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发表时间：
2018-09
影响因子：
2.7
通讯作者：
Aosasa S
中科院分区：
文献类型：
--
作者：
Ono S;Tsujimoto H;Hiraki S;Aosasa S
手术损伤可能是一种危及生命的并发症，不仅是由于损伤本身，还由于对损伤的免疫反应以及随后发生的感染，很容易导致败血症。脓毒症仍然是大多数重症监护室中死亡的主要原因。几项备受瞩目的脓毒症治疗试验的不利结果导致研究人员表示，脓毒症研究需要一个新的方向。脓毒症期间发生的免疫反应的特点是细胞因子介导的高炎症阶段（大多数患者可以存活）和随后的免疫抑制阶段。因此，改善宿主免疫力的疗法可能会增加脓毒症患者的生存率。许多机制导致脓毒症诱导的免疫抑制，包括免疫细胞凋亡、调节性 T 细胞增加、CD4+ T 细胞上程序性细胞死亡 1 的表达以及细胞衰竭。最近发现的免疫调节分子包括白细胞介素-7、白细胞介素-15 和抗程序性细胞死亡 1。最近的研究表明，免疫辅助治疗是脓毒症治疗的下一个重大进展。
Surgical injury can be a life‐threatening complication, not only due to the injury itself, but also due to immune responses to the injury and subsequent development of infections, which readily result in sepsis. Sepsis remains the leading cause of death in most intensive care units. Unfavorable outcomes of several high‐profile trials in the treatment of sepsis have led researchers to state that sepsis studies need a new direction. The immune response that occurs during sepsis is characterized by a cytokine‐mediated hyper‐inflammatory phase, which most patients survive, and a subsequent immunosuppressive phase. Therefore, therapies that improve host immunity might increase the survival of patients with sepsis. Many mechanisms are responsible for sepsis‐induced immunosuppression, including apoptosis of immune cells, increased regulatory T cells and expression of programmed cell death 1 on CD4+ T cells, and cellular exhaustion. Immunomodulatory molecules that were recently identified include interleukin‐7, interleukin‐15, and anti‐programmed cell death 1. Recent studies suggest that immunoadjuvant therapy is the next major advance in sepsis treatment.
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DOI：
10.1186/cc10112
发表时间：
2011
期刊：
Critical care (London, England)
影响因子：
--
作者：
Guignant C;Lepape A;Huang X;Kherouf H;Denis L;Poitevin F;Malcus C;Chéron A;Allaouchiche B;Gueyffier F;Ayala A;Monneret G;Venet F
通讯作者：
Venet F
影响因子：
5.7
作者：
Flohe, Stefanie B.;Agrawal, Hemant;Schade, F. Ulrich
通讯作者：
Schade, F. Ulrich
影响因子：
120.7
作者：
Boomer, Jonathan S.;To, Kathleen;Chang, Kathy C.;Takasu, Osamu;Osborne, Dale F.;Walton, Andrew H.;Bricker, Traci L.;Jarman, Stephen D., II;Kreisel, Daniel;Krupnick, Alexander S.;Srivastava, Anil;Swanson, Paul E.;Green, Jonathan M.;Hotchkiss, Richard S.
通讯作者：
Hotchkiss, Richard S.
影响因子：
4.3
作者：
Casey, LC
通讯作者：
Casey, LC
影响因子：
3
作者：
Hiraki, Shuhichi;Ono, Satoshi;Mochizuki, Hidetaka
通讯作者：
Mochizuki, Hidetaka