Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.

Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.
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含有小鼠 6 号染色体和人类 7 号染色体上基因的同源盒的遗传和细胞遗传学定位。

DOI:
10.1002/j.1460-2075.1986.tb04585.x
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发表时间:
1986
期刊:
The EMBO journal
影响因子:
--
通讯作者:
Lehrach,H
Lehrach,H
中科院分区:
--
文献类型:
--
作者:
Bućan,M;Yang-Feng,T;Colberg-Poley,AM;Wolgemuth,DJ;Guenet,JL;Francke,U;Lehrach,H

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通过体细胞遗传学、原位杂交和Mus spretus-Mus musculus回交定位系统,将来自m6同源盒簇的探针定位到小鼠6号染色体。此外,已使用相同的回交系统和B X D重组近交系集对含有cDNA的睾丸特异性同源盒克隆HBT-1进行了作图。证明了m6簇和HBT-1之间的密切遗传和物理联系,将这些序列定位于含有同源盒基因的相同局部簇。IgK和Tcrb之间的这一簇的图谱位置与形态突变缺指(Hd)相一致。在小鼠6号染色体的一个区域和人类7号染色体的长臂之间观察到了共线性,包括标记物Cpa、Tcrb和Try-1。在这里,我们将与小鼠m6探针杂交的人类序列定位在7号染色体的短臂上,打破了同线性区域。
Probes from the m6 homeo box cluster were mapped to mouse chromosome 6 by somatic cell genetics, in situ hybridisation, and by a Mus spretus‐‐Mus musculus backcross mapping system. In addition, the testis‐specific homeo box containing cDNA, clone, HBT‐1, has been mapped using the same back‐cross system and the B X D recombinant inbred strain set. Close genetic and physical linkage between the m6 cluster and HBT‐1 was demonstrated, positioning these sequences to the same local cluster of homeo box containing genes. The map location of this cluster between IgK and Tcrb coincides with the morphological mutation hypodactyly (Hd). Synteny has been observed between a region of mouse chromosome 6 and the long arm of human chromosome 7 encompassing the markers Cpa, Tcrb and Try‐1. Here we localise human sequences hybridising to the mouse m6 probes to the short arm of chromosome 7, breaking the region of synteny.
高分辨率胰蛋白酶-吉姆萨带状人类染色体的表意文字。
DOI: --
发表时间: 1978
期刊: Cytogenetics and Cell Genetics
影响因子: --
作者:
N. Oliver;U. Francke
通讯作者: U. Francke
大鼠肝癌×人胎肝细胞杂交体中人α1-抗胰蛋白酶基因的激活取决于人14号染色体的存在
DOI: --
发表时间: 1983
期刊: Somatic Cell Genetics
影响因子: --
作者:
S. Pearson;P. Tetri;Donna L. George;Uta Francke
通讯作者: Uta Francke