Can the Loudness Dependence of Auditory Evoked Potentials and Suicidality Be Used to Differentiate between Depressive Patients with and without Bipolarity.
Can the Loudness Dependence of Auditory Evoked Potentials and Suicidality Be Used to Differentiate between Depressive Patients with and without Bipolarity.
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DOI：
10.4306/pi.2013.10.2.143
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发表时间：
2013-06
影响因子：
2.7
通讯作者：
Lee SH
中科院分区：
文献类型：
--
作者：
Park YM;Lee SH
本研究旨在检验以下假设：听觉诱发电位的响度依赖性（LDAEP）可用于预测重度抑郁发作患者是否存在双相情感障碍。本研究纳入了 61 名患者组成的队列，这些患者在使用第四版《精神疾病诊断和统计手册》文本修订版的 Axis I 进行诊断后符合重度抑郁症 (MDD) 标准，并且没有轻躁狂或躁狂发作史。根据患者在韩国版情绪障碍问卷 (K-MDQ) 中是否取得积极评分，将患者分为两个亚组。在开始使用 5-羟色胺药物治疗之前，通过测量听觉事件相关电位来评估 LDAEP。阳性筛查组的 Barratt 冲动量表 (BIS) 评分 (81.24±11.87) 也高于阴性筛查组 (73.30±14.92；p=0.039，独立 t 检验)。然而，LDAEP、贝克抑郁量表、汉密尔顿抑郁评定量表、贝克绝望量表（BHS）和汉密尔顿焦虑量表得分在它们之间没有显着差异。当进行二元logistic回归分析时，K-MDQ的阳性或阴性亚组与BIS或贝克自杀意念量表（BSS）评分之间的关系也显着（分别为p=0.017，p=0.038）。我们发现，患有和不患有双相情感障碍的抑郁症患者的 LDAEP 没有显着差异。然而，我们的研究根据 BIS 或 BSS 评分中的 K-MDQ 是否取得正分，揭示了两个亚组之间的差异。
This study aimed to test the hypothesis that the loudness dependence of auditory evoked potentials (LDAEP) can be used to predict the presence of bipolarity in patients with major depressive episodes. A cohort of 61 patients who met the criteria for major depressive disorder (MDD) following diagnosis using Axis I of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders-text revision, and who had no history of hypomanic or manic episodes was included in this study. The patients were stratified into two subgroups based on whether or not they achieved a positive score for the Korean versions of the Mood Disorder Questionnaire (K-MDQ). The LDAEP was evaluated by measuring the auditory event-related potentials before beginning medication with serotonergic agents. The Barratt Impulsiveness Scale (BIS) score was also higher for the positive screening group (81.24±11.87) than for the negative screening group (73.30±14.92; p=0.039, independent t-test). However, the LDAEP, Beck Depression Inventory, Hamilton Depression Rating Scale, Beck Hopelessness Scale (BHS), and Hamilton Anxiety Scale scores did not differ significantly between them. When binary logistic regression analysis was carried, the relationship between the positive or negative subgroups for K-MDQ and BIS or Beck Scale for Suicidal Ideation (BSS) score was also significant (respectively, p=0.017, p=0.038). We found that LDAEP was not significantly different between depressive patients with and without bipolarity. However, our study has revealed the difference between two subgroups based on whether or not they achieved a positive score for the K-MDQ in BIS or BSS score.
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影响因子：
7.3
作者：
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通讯作者：
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影响因子：
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影响因子：
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