Serotonergic dysfunction in patients with bipolar disorder assessed by the loudness dependence of the auditory evoked potential.
Serotonergic dysfunction in patients with bipolar disorder assessed by the loudness dependence of the auditory evoked potential.
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DOI：
10.4306/pi.2012.9.3.298
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发表时间：
2012-09
影响因子：
2.7
通讯作者：
Lee SH
中科院分区：
文献类型：
--
作者：
Lee KS;Park YM;Lee SH
听觉诱发电位（LDAEP）的响度依赖性被认为是5-羟色胺系统功能的一个标志。本研究旨在探讨双相情感障碍患者多种心境状态（抑郁、躁狂、心境正常）的LDAEP及其临床意义。共89名受试者，包括35名双相情感障碍患者，32名精神分裂症患者和22名健康对照进行了评价。双相情感障碍病例包括10名抑郁症患者、15名躁狂症患者和10名心境正常患者。在5种刺激强度下测量N1/P2峰-峰振幅，并计算LDAEP作为线性回归的斜率。计算皮质和源LDAEP值。LDAEP根据情绪状态而变化，并且在正常情绪、抑郁和躁狂的情况下明显更强。皮质LDAEP在双相心境正常患者中明显强于精神分裂症患者，在双相抑郁患者中强于精神分裂症患者，在健康对照组中强于精神分裂症患者，在健康对照组中强于双相躁狂患者。与精神分裂症相比，双相情感正常、双相抑郁和双相躁狂患者的源LDAEP明显更强，双相情感正常患者的源LDAEP比双相躁狂患者的源LDAEP更强。相对于非精神病性特征，精神病性特征减弱了源LDAEP。抑郁症状的严重程度与源LDAEP呈负相关。这些发现表明，双相情感障碍患者的血清素活性可能会根据情绪状态而变化。应使用未接受过药物治疗的受试者进行纵向随访研究。
The loudness dependence of the auditory evoked potential (LDAEP) is suggested to be a marker of serotonin system function. This study explored the LDAEP of multiple mood statuses (depression, mania, and euthymia) and its clinical implication in bipolar disorder patients. A total of 89 subjects, comprising 35 patients with bipolar disorder, 32 patients with schizophrenia, and 22 healthy controls were evaluated. The bipolar disorder cases comprised 10 depressed patients, 15 patients with mania, and 10 euthymic patients. The N1/P2 peak-to-peak amplitudes were measured at 5 stimulus intensities, and the LDAEP was calculated as the slope of the linear regression. Both cortical and source LDAEP values were calculated. LDAEP varied according to mood statuses, and was significantly stronger in cases of euthymia, depression, and mania. Cortical LDAEP was significantly stronger in patients with bipolar euthymia compared with schizophrenia, stronger in bipolar depression than in schizophrenia, stronger in healthy controls than in schizophrenia patients, and stronger in healthy controls than in patients with bipolar mania. Source LDAEP was significantly stronger in patients with bipolar euthymia, bipolar depression, and bipolar mania compared with schizophrenia, stronger in bipolar euthymia than in bipolar mania. Psychotic features weakened the source LDAEP relative to nonpsychotic features. The severity of the depressive symptom was negatively correlated with source LDAEP. These findings suggest that the serotonin activity of patients with bipolar disorder may vary according to mood status. A longitudinal follow-up study should be pursued using drug-naive subjects.
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影响因子：
6.6
作者：
Dean, B;Pavey, G;Copolov, D
通讯作者：
Copolov, D
影响因子：
--
作者：
Blumberg, HP;Leung, HC;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
10.6
作者：
Clark, L;Kempton, MJ;Goodwin, GM
通讯作者：
Goodwin, GM
在未经药物的躁郁症抑郁症，正肌和躁狂症中面部情绪加工过程中的神经激活。
影响因子：
10.6
作者：
Hulvershorn, Leslie A.;Karne, Harish;Gunn, Abigail D.;Hartwick, Sarah L.;Wang, Yang;Hummer, Tom A.;Anand, Amit
通讯作者：
Anand, Amit
影响因子：
4.7
作者：
Fuchs, M;Kastner, J;Ebersole, JS
通讯作者：
Ebersole, JS