Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
复制标题
DOI：
10.1371/journal.pone.0108034
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Banks WA
中科院分区：
文献类型：
--
作者：
Dohi K;Kraemer BC;Erickson MA;McMillan PJ;Kovac A;Flachbartova Z;Hansen KM;Shah GN;Sheibani N;Salameh T;Banks WA
各种形式的创伤性脑损伤（TBI）已成为现代社会的主要问题。急性TBI可以转化为慢性疾病，并可能通过诱导氧化应激和神经炎症成为神经退行性疾病（如阿尔茨海默病和帕金森病）的危险因素。在这里，我们研究了饮用水中的抗氧化剂分子氢（分子氢水; mHW）改变由受控皮质撞击（CCI）（一种常用的TBI实验模型）引起的急性变化的能力。我们发现，mHW逆转了CCI诱导的水肿约一半，完全阻断病理性tau蛋白表达，加重了几种细胞因子的早期增加，但在第7天减弱了这种增加，逆转了水通道蛋白-4，HIF-1，MMP-2和MMP-9的蛋白水平的变化，但没有淀粉样β肽1-40或1-42。用mHW治疗还逆转了CCI后4小时与氧化/碳水化合物代谢、细胞因子释放、白细胞或细胞迁移、细胞因子转运、ATP和核苷酸结合相关的基因表达的增加。最后，我们发现，mHW保存或增加ATP水平，并提出了一个新的机制mHW，即ATP生产通过Joborf反应。这些结果表明，饮用水中的分子氢逆转了CCI的许多后遗症，并表明它可能是一种易于管理的，高效的TBI治疗方法。
Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drinking water (molecular hydrogen water; mHW) to alter the acute changes induced by controlled cortical impact (CCI), a commonly used experimental model of TBI. We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1–40 or 1–42. Treatment with mHW also reversed the increase seen 4 h after CCI in gene expression related to oxidation/carbohydrate metabolism, cytokine release, leukocyte or cell migration, cytokine transport, ATP and nucleotide binding. Finally, we found that mHW preserved or increased ATP levels and propose a new mechanism for mHW, that of ATP production through the Jagendorf reaction. These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI.
登录
查看更多内容
影响因子：
5.3
作者：
Deng, Ying;Thompson, Brian M.;Hall, Edward D.
通讯作者：
Hall, Edward D.
影响因子：
16.2
作者：
Ishihara, T;Hong, M;Lee, VMY
通讯作者：
Lee, VMY
DOI：
10.1152/ajpendo.1996.271.4.e636
发表时间：
1996-10-01
影响因子：
5.1
作者：
Pan, WH;Banks, WA;Kastin, AJ
通讯作者：
Kastin, AJ
影响因子：
5.3
作者：
Pan, WH;Kastin, AJ
通讯作者：
Kastin, AJ
影响因子：
3.5
作者：
Guthrie, Chris R.;Schellenberg, Gerard D.;Kraemer, Brian C.
通讯作者：
Kraemer, Brian C.