Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses.
Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses.
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DOI：
10.1016/j.exger.2017.07.002
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发表时间：
2018-07-01
影响因子：
3.9
通讯作者：
Frasca D
中科院分区：
文献类型：
--
作者：
Frasca D
Immune cells with a senescence-associated secretory phenotype increase in the blood of elderly individuals or individuals with age-associated diseases or with infections. Although senescent immune cells do not proliferate, they are transcriptionally and metabolically active and affect the microenvironment through the secretion of pro-inflammatory mediators. An age-driven increase in senescent B, T and NK cells has been reported and the function of these cells has been characterized. Results published by different groups have demonstrated that cell senescence induces the accumulation of terminally-differentiated cells characterized by the arrest of cell proliferation but with an active secretory profile which regulates their function through the activation of pathways integrating senescence and energy-sensing signals. This review will focus on senescent B cells, their increase in aging, age-associated conditions and infections. Similarities with other senescent immune cells will be presented and discussed.
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影响因子：
4
作者：
Campisi, Judith
通讯作者：
Campisi, Judith
影响因子：
13.6
作者：
Freund A;Orjalo AV;Desprez PY;Campisi J
通讯作者：
Campisi J
影响因子：
7.8
作者：
Heikamp EB;Powell JD
通讯作者：
Powell JD
动脉粥样硬化的炎症。
DOI：
10.1161/atvbaha.108.179705
发表时间：
2012-09
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Libby P
通讯作者：
Libby P
影响因子：
3.7
作者：
Lindholm E;Bakhtadze E;Cilio C;Agardh E;Groop L;Agardh CD
通讯作者：
Agardh CD