Ethylmalonic Encephalopathy 1 Protein Is Increased in Colorectal Adenocarcinoma.
Ethylmalonic Encephalopathy 1 Protein Is Increased in Colorectal Adenocarcinoma.
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DOI：
10.21873/anticanres.15286
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发表时间：
2021-10
影响因子：
2
通讯作者：
Shackelford RE
中科院分区：
文献类型：
--
作者：
Ozluk E;Coppola D;Mohammad IZ;Islam T;Ghali G;Kevil CG;Shackelford RE
乙基丙二酸脑病1蛋白（ETHE1）在硫化物催化剂和多硫化物形成中起重要作用。由于硫化物和多硫化物最近已被确定为在癌症中发挥重要作用，我们假设ETHE1表达将在结肠癌中增加。我们使用组织芯片分析比较ETHE1在良性结肠上皮和结肠腺癌中的表达。总共有26例良性结肠上皮样本与122例结肠腺癌进行了比较。与良性结肠上皮相比，ETHE1在结肠腺癌中的表达显著增加（约两倍）。此外，这种表达随着结肠癌肿瘤等级的增加而增加。与良性结肠上皮相比，ETHE1在结肠癌中的表达增加。这些数据，结合以前的研究，表明ETHE1可能有助于结肠癌的发生，促进肿瘤细胞的生物能量学和多硫化物的形成。
Ethylmalonic encephalopathy 1 protein (ETHE1) plays an important role in sulfide catabolism and polysulfide formation. As sulfides and polysulfides have recently been identified as playing important roles in cancer, we hypothesized that ETHE1 expression would be increased in colon cancer. We used tissue microarray analysis to compare ETHE1 expression in benign colonic epithelium compared to colonic adenocarcinoma. In total, 26 benign colonic epithelial samples were compared to 122 cases of colonic adenocarcinomas. Compared to benign colonic epithelium, ETHE1 expression was significantly increased (~two-fold) in colonic adenocarcinoma. Additionally, this expression increased with increasing colon cancer tumor grades. ETHE1 expression is increased in colon cancer compared to benign colonic epithelium. These data, combined with previous studies, suggest that ETHE1 may contribute to colon carcinogenesis by promoting tumor cell bioenergetics and polysulfide formation.
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影响因子：
11.4
作者：
Honda K;Hishiki T;Yamamoto S;Yamamoto T;Miura N;Kubo A;Itoh M;Chen WY;Takano M;Yoshikawa T;Kasamatsu T;Sonoda S;Yoshizawa H;Nakamura S;Itai Y;Shiota M;Koike D;Naya M;Hayakawa N;Naito Y;Matsuura T;Iwaisako K;Masui T;Uemoto S;Nagashima K;Hashimoto Y;Sakuma T;Matsubara O;Huang W;Ida T;Akaike T;Masugi Y;Sakamoto M;Kato T;Ino Y;Yoshida H;Tsuda H;Hiraoka N;Kabe Y;Suematsu M
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Suematsu M
影响因子：
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通讯作者：
Kimura H
影响因子：
2
作者：
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通讯作者：
Shackelford RE
影响因子：
4
作者：
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通讯作者：
Tiranti, V.
影响因子：
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作者：
Witherspoon, Mavee;Sandu, Davinder;Lipkin, Steven
通讯作者：
Lipkin, Steven