Cystathione β-Synthase Is Increased in Thyroid Malignancies.
Cystathione β-Synthase Is Increased in Thyroid Malignancies.
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DOI：
10.21873/anticanres.12958
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发表时间：
2018-11
影响因子：
2
通讯作者：
Shackelford RE
中科院分区：
文献类型：
--
作者：
Turbat-Herrera EA;Kilpatrick MJ;Chen J;Meram AT;Cotelingam J;Ghali G;Kevil CG;Coppola D;Shackelford RE
胱胱甘肽β-合成酶（CBS）通过反式硫酸途径催化同型半胱氨酸和半胱氨酸转化为硫化氢（H2S）和胱胱甘肽。在几种不同的人类恶性肿瘤中，CBS蛋白表达水平升高，蛋白表达升高与肿瘤分期、间变、转移和化疗耐药性等参数相关。本研究采用组织微阵列技术检测CBS在良性甲状腺组织、甲状腺癌细胞瘤、甲状腺滤泡腺瘤以及滤泡癌、乳头状癌、间变性癌和甲状腺髓样癌中的表达。与良性甲状腺组织相比，CBS在所有类型甲状腺癌中的表达均增加，但在甲状腺滤泡腺瘤或癌细胞瘤中未见表达增加。在比较甲状腺腺瘤和滤泡癌的烟酰胺磷酸核糖基转移酶（NAMPT）组织微阵列分析中也观察到类似的模式。我们首次发现h2s合成酶在甲状腺恶性肿瘤中起作用。此外，我们的数据表明，CBS和NAMPT免疫组织化学可能有助于区分滤泡腺瘤和滤泡癌。
Cystathione β-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway. CBS protein expression levels are increased in several different human malignancies, with increased protein expression correlating with parameters such as tumor stage, anaplasia, metastases, and chemotherapy resistance. This study employed tissue microarrays to examine CBS expression in benign thyroid tissue, thyroid oncocytomas, thyroid follicular adenomas, and in follicular, papillary, anaplastic, and medullary thyroid carcinomas. CBS expression was increased in all thyroid carcinomas types compared to benign thyroid tissue, but not in thyroid follicular adenomas or oncocytomas. A similar pattern was observed for nicotinamide phosphoribosyltransferase (NAMPT) tissue microarray analysis comparing thyroid adenomas and follicular carcinomas. For the first time, we showed that an H2S-syntheszing enzyme plays a role in thyroid malignancies. Additionally, our data suggest that CBS and NAMPT immunohistochemistry may be useful in differentiating follicular adenomas from follicular carcinomas.
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影响因子：
5.8
作者：
Nikiforova, MN;Lynch, RA;Nikiforov, YE
通讯作者：
Nikiforov, YE
影响因子：
--
作者：
Shackelford, Rodney E;Mayhall, Kim;Coppola, Domenico
通讯作者：
Coppola, Domenico
DOI：
10.1111/j.1365-2362.2009.02162.x
发表时间：
2009-08-01
影响因子：
5.5
作者：
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通讯作者：
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影响因子：
2
作者：
Meram AT;Chen J;Patel S;Kim DD;Shirley B;Covello P;Coppola D;Wei EX;Ghali G;Kevil CG;Shackelford RE
通讯作者：
Shackelford RE
影响因子：
2
作者：
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通讯作者：
Shackelford R