The impact of consuming iron from non-food sources on iron status in developing countries
The impact of consuming iron from non-food sources on iron status in developing countries
复制标题
发展中国家消费非食物来源的铁对铁状况的影响
DOI：
10.1017/s1368980000000434
复制
发表时间：
2000
影响因子：
3.2
通讯作者：
Ian Darnton
中科院分区：
文献类型：
--
作者：
Philip W.J. Harvey;Patricia B. Dexter;Ian Darnton
摘要目的探讨污染物铁和食土行为对发展中国家居民铁摄入量和铁营养状况的影响。通过检索Medline和Agricola，从适当的其他文本和来自USAID的营养素干预机会（OMNI）项目的三份报告中确定了用于审查的设计文献。发展中国家居民的膳食铁摄入量普遍较高，但铁缺乏症仍然普遍存在。这种明显的矛盾是因为铁主要以非血红素形式被消耗，这是很难吸收的。一些非血红素铁来自土壤、灰尘和水中的铁对食物的污染;铁在储存和烹饪过程中渗入食物;食物加工过程中的污染，如碾磨;以及食土行为。结果尽管污染物铁对铁摄入量的贡献已有很好的记录，但其吸收以及对铁状况的影响却没有。为了可用于吸收，污染物铁必须加入共同的非血红素池，即可交换的。可交换污染物铁的吸收与食物中其他成分的相互作用与食物固有的非血红素铁相同。有限的可用证据表明可交换性存在很大差异。在污染铁的显著部分加入池的情况下，对铁状态的影响可能是实质性的。没有一个简单的方法来预测交换率，在任何特定情况下，污染物铁对铁状态的影响是不确定的。结论：已知增加食物固有铁吸收的干预措施也会增加任何污染铁的吸收，这些污染铁已经加入了共同的游泳池。由于土壤和粘土中含有抑制成分，铁摄入量增加导致的食土行为的任何积极影响都是极不可能的。旨在增加污染物铁摄入量的方法的有效性仍然令人鼓舞，但不确定。采用多重干预措施的办法对于减少缺铁性贫血仍然至关重要。
Abstract Objective To determine the impact of contaminant iron and geophagy on iron intake and status of persons living in developing countries. Design Literature for review was identified by searching Medline and Agricola, from appropriate other texts and from three reports from the Opportunities for Micronutrient Interventions (OMNI) Project of USAID. Setting The dietary intake of iron by people living in developing countries is generally high but iron deficiency remains prevalent. This apparent paradox is because the iron being consumed is predominantly in the non-haem form, which is poorly absorbed. Some of this non-haem iron is from contamination of food with iron from soil, dust and water; iron leaching into food during storage and cooking; contamination during food processing such as milling; and the practice of geophagy. Results Although the contribution of contaminant iron to overall iron intake is well documented, its absorption and thus its impact on iron status is not. To be available for absorption, contaminant iron must join the common non-haem pool, i.e. be exchangeable. The absorption of exchangeable contaminant iron is subject to the same interactions with other constituents in the diet as the non-haem iron that is intrinsic to food. The limited available evidence suggests wide variation in exchangeability. In situations where a significant fraction of the contaminating iron joins the pool, the impact on iron status could be substantial. Without a simple method for predicting exchangeability, the impact of contaminant iron on iron status in any particular situation is uncertain. Conclusions Interventions known to increase the absorption of iron intrinsic to foods will also increase absorption of any contaminant iron that has joined the common pool. Any positive effect of geophagy resulting from an increased intake of iron is highly unlikely, due to inhibiting constituents contained in soils and clays. The efficacy of approaches designed to increase the intake of contaminant iron remains encouraging but uncertain. An approach using multiple interventions will continue to be essential to reduce iron deficiency anaemia.
影响因子：
7.1
作者：
COOK, JD
通讯作者：
COOK, JD
影响因子：
20.3
作者：
Moyo,VM;Mandishona,E;Hasstedt,SJ;Gangaidzo,IT;Gomo,ZA;Khumalo,H;Saungweme,T;Kiire,CF;Paterson,AC;Bloom,P;MacPhail,AP;Rouault,T;Gordeuk,VR
通讯作者：
Gordeuk,VR
评估人类和大鼠非血红素铁吸收的饮食决定因素。
DOI：
10.1093/ajcn/54.4.723
发表时间：
1991
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Reddy,MB;Cook,JD
通讯作者：
Cook,JD