Regulation of FGF23: Beyond Bone.
Regulation of FGF23: Beyond Bone.
复制标题
DOI：
10.1007/s11914-021-00703-w
复制
发表时间：
2021-12
影响因子：
4.3
通讯作者：
Babitt JL
中科院分区：
文献类型：
--
作者：
Simic P;Babitt JL
成纤维细胞生长因子-23（FGF 23）是一种骨和骨髓源性激素，对维持磷酸盐稳态至关重要。FGF 23的主要作用是通过减少肾脏磷酸盐重吸收和1，25-二羟维生素D合成来降低血清磷酸盐水平。FGF 23缺乏引起高磷酸盐血症和异位钙化，而FGF 23过量引起低磷酸盐血症和骨骼缺陷。过量的FGF 23也与肾脏疾病相关，其中它与发病率和死亡率增加相关。因此，FGF 23水平受到严格调控，但其机制仍不完全清楚。除了骨矿物质因子外，其他因子包括铁、促红细胞生成素、炎症、能量和代谢调节FGF 23。所有这些因素都影响Fgf 23的表达，而有些还调节FGF 23蛋白的切割。相反，FGF 23可能在调节这些生物学过程中发挥功能性作用。了解FGF 23和非骨矿物质因子之间的双向关系为FGF 23的调节和功能提供了新的见解。
Fibroblast growth factor-23 (FGF23) is a bone- and bone marrow-derived hormone that is critical to maintain phosphate homeostasis. The principal actions of FGF23 are to reduce serum phosphate levels by decreasing kidney phosphate reabsorption and 1,25-dihydroxyvitamin D synthesis. FGF23 deficiency causes hyperphosphatemia and ectopic calcifications, while FGF23 excess causes hypophosphatemia and skeletal defects. Excess FGF23 also correlates with kidney disease, where it is associated with increased morbidity and mortality. Accordingly, FGF23 levels are tightly regulated, but the mechanisms remain incompletely understood. In addition to bone mineral factors, additional factors including iron, erythropoietin, inflammation, energy and metabolism regulate FGF23. All these factors affect Fgf23 expression, while some also regulate FGF23 protein cleavage. Conversely, FGF23 may have a functional role in regulating these biologic processes. Understanding the bi-directional relationship between FGF23 and non-bone mineral factors is providing new insights into FGF23 regulation and function.
登录
查看更多内容
影响因子：
19.6
作者：
Babitt, Jodie L.;Eisenga, Michele F.;Drueke, Tilman B.
通讯作者：
Drueke, Tilman B.
影响因子：
10.1
作者：
Agoro R;Park MY;Le Henaff C;Jankauskas S;Gaias A;Chen G;Mohammadi M;Sitara D
通讯作者：
Sitara D
影响因子：
41.5
作者：
Farrow, Emily G.;White, Kenneth E.
通讯作者：
White, Kenneth E.
影响因子：
5.8
作者：
Bacchetta, Justine;Dubourg, Laurence;Cochat, Pierre
通讯作者：
Cochat, Pierre
影响因子：
19.6
作者：
Egli-Spichtig, Daniela;Silva, Pedro Henrique Imenez;Wagner, Carsten A.
通讯作者：
Wagner, Carsten A.