Effects of Fetal Alcohol Exposure on Fever, Sickness Behavior, and Pituitary–Adrenal Activation Induced by Interleukin-1β in Young Adult Rats
Effects of Fetal Alcohol Exposure on Fever, Sickness Behavior, and Pituitary–Adrenal Activation Induced by Interleukin-1β in Young Adult Rats
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胎儿酒精暴露对年轻成年大鼠发烧、疾病行为和白细胞介素 1β 诱导的垂体-肾上腺激活的影响
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
A. Taylor
中科院分区：
文献类型：
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作者：
R. Yirmiya;D. Tio;A. Taylor
Exposure to alcohol in utero can lead to long-lasting impairments of immune functions and to decreased resistance to infectious agents. We have previously reported that fetal alcohol-exposed rats show markedly decreased lipopolysaccharide-induced fever and suggested that fetal alcohol exposure (FAE) impairs the communication between the immune and the nervous systems. The present study examined the effects of interleukin-1 beta (IL-1) on body temperature, motor activity, ingestive behavior, and pituitary-adrenal activation in fetal alcohol-exposed and control rats. Transmitters for continuous biotelemetric recording of body temperature and motor activity were implanted i.p. in normal (N) adult rats, offspring of dams fed a liquid diet supplemented with ethanol (E), and pair-fed control offspring (P). In one experiment, rats were injected with either IL-1 (2 micrograms/kg, i.p.) or saline at the beginning of the light period. IL-1 produced a marked increase in body temperature, which was significantly lower in E rats than in N and P rats. In a second experiment, rats were administered either IL-1 (10 micrograms/kg, i.p.) or saline at the beginning of the dark period. IL-1 produced an initial transient hypothermia followed by a longer-lasting hyperthermia. During the hyperthermic phase, fever in the E rats was lower than in the P rats, but comparable to fever in the N rats. IL-1 significantly reduced motor activity, during both the hypothermic and hyperthermic phases. This effect was similar in all prenatal treatment groups. IL-1 also suppressed 24-h food consumption in N and P rats and water consumption in P rats, but it did not produce significant anorexia and adypsia in E rats. A third experiment demonstrated that IL-1 (2 micrograms/ kg, ip) significantly increased ACTH and corticosterone release in all prenatal treatment groups. IL-1-induced corticosterone secretion was attenuated in P offspring, compared to both E and N rats. Together, these findings indicate that exposure to ethanol in utero produces impairments in mechanisms that mediate the effects of IL-1 on body temperature (particularly during the light period) and ingestive behavior, but not on motor activity and pituitary-adrenal activation. In view of the adaptive role of IL-1-induced fever and anorexia, these impairments may contribute to the decreased resistance to infections observed in animals and humans following FAE.
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产前乙醇暴露：怀孕母鼠和后代的垂体肾上腺活动。
DOI：
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发表时间：
1982
期刊：
Neurobehavioral toxicology and teratology
影响因子：
--
作者：
Weinberg,J;Gallo,PV
通讯作者：
Gallo,PV
棕色脂肪组织去甲肾上腺素能神经支配在产前酒精暴露后体温调节缺陷中的作用。
DOI：
10.1111/j.1530-0277.1993.tb00786.x
发表时间：
1993
期刊：
Alcoholism, clinical and experimental research
影响因子：
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作者：
Zimmerberg,B;Carson,EA;Kaplan,LJ;Zuniga,JA;True,RC
通讯作者：
True,RC
子宫内的酒精暴露会导致 T 细胞功能减弱以及大脑促肾上腺皮质激素释放因子和 ACTH 含量的改变。
DOI：
10.1111/j.1530-0277.1989.tb00350.x
发表时间：
1989
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Redei,E;Clark,WR;McGivern,RF
通讯作者：
McGivern,RF
产前乙醇暴露会改变肾上腺皮质对可预测和不可预测压力源的反应。
DOI：
10.1016/0741-8329(92)90043-a
发表时间：
1992
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
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作者：
Weinberg,J
通讯作者：
Weinberg,J
人 IL-1 受体拮抗剂可部分抑制 Fischer 大鼠的 LPS 发热，但不能抑制血浆 IL-6 水平。
DOI：
10.1152/ajpregu.1992.263.3.r653
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Smith,BK;Kluger,MJ
通讯作者：
Kluger,MJ