Infant brain regional cerebral blood flow increases supporting emergence of the default-mode network.
Infant brain regional cerebral blood flow increases supporting emergence of the default-mode network.
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DOI：
10.7554/elife.78397
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发表时间：
2023-01-24
期刊：
影响因子：
7.7
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Yu Q;Ouyang M;Detre J;Kang H;Hu D;Hong B;Fang F;Peng Y;Huang H
人类婴儿期的特点是最快速的区域脑血流量（rCBF）增加整个生命周期和出现一个基本的脑系统默认模式网络（DMN）。然而，婴儿rCBF如何在整个大脑中时空变化以及rCBF如何增加支持功能网络（如DMN）的出现仍然未知。在这里，通过获取尖端的多模态MRI，包括伪连续动脉自旋标记灌注MRI和静息态功能MRI的48个婴儿的横截面，我们阐明了前所未有的四维时空婴儿rCBF框架和特定区域的生理功能耦合在婴儿期。我们发现DMN的rCBF增加速度比视觉和感觉运动网络快。我们还发现，强烈耦合的rCBF和网络强度的增加，特别是在DMN，这表明更快的局部血流增加，以满足DMN成熟的神经元代谢的需求。这些结果提供了深入了解脑功能网络出现的生理机制，并在改变网络成熟的大脑疾病有重要意义。
Human infancy is characterized by most rapid regional cerebral blood flow (rCBF) increases across lifespan and emergence of a fundamental brain system default-mode network (DMN). However, how infant rCBF changes spatiotemporally across the brain and how the rCBF increase supports emergence of functional networks such as DMN remains unknown. Here, by acquiring cutting-edge multi-modal MRI including pseudo-continuous arterial-spin-labeled perfusion MRI and resting-state functional MRI of 48 infants cross-sectionally, we elucidated unprecedented 4D spatiotemporal infant rCBF framework and region-specific physiology–function coupling across infancy. We found that faster rCBF increases in the DMN than visual and sensorimotor networks. We also found strongly coupled increases of rCBF and network strength specifically in the DMN, suggesting faster local blood flow increase to meet extraneuronal metabolic demands in the DMN maturation. These results offer insights into the physiological mechanism of brain functional network emergence and have important implications in altered network maturation in brain disorders.
影响因子：
3.7
作者：
Gur, Ruben C.;Ragland, J. Daniel;Reivich, Martin;Greenberg, Joel H.;Alavi, Abass;Gur, Raquel E.
通讯作者：
Gur, Raquel E.