The Influence of Body Mass Index on Glucocorticoid Insensitivity in Chronic Rhinosinusitis with Nasal Polyps.
The Influence of Body Mass Index on Glucocorticoid Insensitivity in Chronic Rhinosinusitis with Nasal Polyps.
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DOI：
10.3390/jpm12111935
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发表时间：
2022-11-21
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Zhang Y;Shen S;Liu Y;Wang Z;Wang Q;Li Y;Wang C;Lan F;Zhang L
背景：慢性鼻窦炎鼻息肉(CRSwNP)对糖皮质激素(GC)不敏感的原因尚不完全清楚。在这里，我们研究了体重指数(BMI)对嗜酸性CRSwNP(EosCRSwNP)和非嗜酸性CRSwNP(Non EosCRSwNP)患者GC不敏感性的影响。方法：对699例CRSwNP患者给予口服甲基强的松龙治疗2周(24 mg/d)。分析具有不同BMI水平和表型的GC敏感和GC不敏感CRSwNP患者的患者人口统计学和临床特征。结果：35.3%的CRSwNP患者对GC不敏感，GC不敏感患者多为男性或有超重和肥胖倾向。Logistic回归分析进一步证实超重和肥胖是CRSwNP患者GC不敏感的独立危险因素(优势比=1.584，p=0.049)。与体重不足和正常体重的患者相比，超重和肥胖患者更有可能对GC不敏感，特别是在eosCRSwNP组，但在非eosCRSwNP组中不是。然而，体重不足和体重正常的患者和超重和肥胖的GC不敏感的eosCRSwNP患者在嗜酸性粒细胞、中性粒细胞和息肉复发率方面没有显著差异。结论：总而言之，我们的研究结果首次证明，体重指数有助于eosCRSwNP患者的GC不敏感。
Background: Reasons for glucocorticoid (GC) insensitivity in chronic rhinosinusitis with nasal polyps (CRSwNP) are not completely clear. Here, we investigate the influence of body mass index (BMI) on GC insensitivity in eosinophilic CRSwNP (eosCRSwNP) and noneosinophilic CRSwNP (noneosCRSwNP) patients. Methods: We recruited 699 CRSwNP patients and gave them a course of oral methylprednisolone for 2 weeks (24 mg/day). Patient demographics and clinical features were analyzed in both GC-sensitive and GC-insensitive CRSwNP patients with different BMI levels and phenotypes. Results: 35.3% of recruited CRSwNP patients were GC-insensitive, and the majority of GC-insensitive patients were males or prone to overweight & obese. Logistic regression analysis further confirmed that being overweight & obese was an independent risk factor for GC-insensitive of CRSwNP patients (odds ratio = 1.584, p = 0.049). Compared to underweight & normal-weight patients, overweight & obese patients were more likely to be GC insensitivity, particularly in the eosCRSwNP group, but not in the noneosCRSwNP group. However, there was no significant difference between the underweight & normal weight and the overweight & obese GC-insensitive eosCRSwNP patients regarding the number of infiltrated eosinophils, neutrophils, and polyp recurrence rate. Conclusions: Collectively, our findings demonstrate for the first time that BMI contributes to GC insensitivity in eosCRSwNP patients.
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影响因子：
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作者：
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通讯作者：
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