Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study.
Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study.
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DOI：
10.1136/bmjopen-2020-047230
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发表时间：
2021-05-25
期刊：
影响因子：
2.9
通讯作者：
Cho HJ
中科院分区：
文献类型：
--
作者：
Nam JS;Roh YH;Fahad WA;Noh HE;Ha JG;Yoon JH;Kim CH;Cho HJ
我们对韩国全国健康和营养检查调查的数据进行了横断面分析，以评估肥胖与伴有鼻息肉（CRSwNP）或不伴有鼻息肉（CRSsNP）的慢性鼻窦炎之间的关联。健康调查数据的回顾性横断面分析。对韩国代表性人口的自愿调查。总共包括 32 384 名 19 岁或以上且拥有 CRS 和肥胖可用数据的个体。 CRSwNP 或 CRSsNP 的诊断由经过培训的耳鼻喉科医生通过鼻窦内窥镜检查和病史调查进行。分别使用体重指数（BMI）和腰围（WC）来诊断全身性肥胖和向心性肥胖。根据 BMI 和 WC，使用多变量逻辑回归分析来阐明 CRSwNP 或 CRSsNP 与肥胖之间的关联。招募非肥胖个体作为对照。一般肥胖组（OR，1.438；95% CI，1.170 至 1.768；p<0.001）和中心性肥胖组（OR，1.251；95% CI，1.031 至 1.520；p=0.033）中 CRSwNP 的患病率高于对照组。 CRSsNP 的患病率与肥胖无关。在逻辑回归分析中，向心性肥胖组中嗅觉功能障碍（OR，1.329；95% CI，1.137至1.553；p<0.001）和脓性分泌物（OR，1.383；95% CI，1.193至1.603；p<0.001）的发生率高于对照组。我们证明了 CRSwNP 与全身性肥胖和中心性肥胖之间的关联。为了更好地了解 CRSwNP 的发病机制，有必要进一步研究这种相关性的机制。
We performed a cross-sectional analysis of data from the nationwide Korea National Health and Nutrition Examination Survey to evaluate the association between obesity and chronic rhinosinusitis with nasal polyps (CRSwNP) or without nasal polyp (CRSsNP). Retrospective cross-sectional analysis of health survey data. Voluntary survey of representative South Korean populations. In total, 32 384 individuals aged 19 years or older with available data on CRS and obesity were included. Diagnosis of CRSwNP or CRSsNP was performed by trained otolaryngologists through sinus endoscopy and surveys of medical history. General and central obesity was diagnosed using body mass index (BMI) and waist circumference (WC), respectively. A multivariate logistic regression analysis was used to clarify the association between CRSwNP or CRSsNP and obesity according to BMI and WC. Non-obese individuals were recruited as controls. The prevalence of CRSwNP was higher in the general (OR, 1.438; 95% CI, 1.170 to 1.768; p<0.001) and central (OR, 1.251; 95% CI, 1.031 to 1.520; p=0.033) obesity groups than in the control group. Prevalence of CRSsNP was not correlated with obesity. In a logistic regression analysis, olfactory dysfunction (OR, 1.329; 95% CI, 1.137 to 1.553; p<0.001) and purulent discharge (OR, 1.383; 95% CI, 1.193 to 1.603; p<0.001) showed a higher incidence in the central obesity group than in the control group. We demonstrated an association between CRSwNP and general and central obesity. Further investigations on the mechanism underlying this correlation are necessary for an improved understanding of the pathogenesis of CRSwNP.
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DOI：
10.1016/j.jaci.2015.12.1307
发表时间：
2016-05
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Han YY;Forno E;Gogna M;Celedón JC
通讯作者：
Celedón JC
影响因子：
2.6
作者：
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通讯作者：
Mittelman SD
影响因子：
6.4
作者：
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通讯作者：
Choi, Hyo Geun
影响因子：
4.5
作者：
Koh, Jang Hyun;Koh, Sang Baek;Chung, Choon Hee
通讯作者：
Chung, Choon Hee
影响因子：
7.2
作者：
Fokkens, Wytske J.;Lund, Valerie J.;Wormald, Peter John
通讯作者：
Wormald, Peter John