The association between apathy and frailty in older adults: a new investigation using data from the Mapt study
The association between apathy and frailty in older adults: a new investigation using data from the Mapt study
复制标题
老年人冷漠与虚弱之间的关联：利用 Mapt 研究数据进行的一项新调查
作者：
Ilaria Parrotta;M. Maltais;Y. Rolland;D. Spampinato;P. Robert;P. de Souto Barreto;B. Vellas
冷漠是一种行为综合征，被认为与虚弱有相似的神经生理通路。方法采用MAPT（一项为期3年、随机、多中心、安慰剂对照试验）的数据，通过横断面分析来检验虚弱（根据Fried 's虚弱表型）和冷漠（由老年抑郁症量表中的3个项目定义）之间的关系。无痴呆参与者（1679人，平均年龄75岁）。结果有序逻辑回归显示，在调整混杂因素后，冷漠个体被评为虚弱的概率高出两倍（OR 2.20, 95% CI 1.7-2.9）。与健壮的参与者相比，冷漠的个体被评为虚弱前的可能性高出两倍（RRR 2.1; 95% CI 1.5-2.8），被评为虚弱的可能性高出三倍（RRR 3.5, 95% CI 1.8-6.9）。结论尽管冷漠和虚弱之间的关联数据很少，但这些情况可能具有共同的生理机制，并且被发现是密切相关的。脆弱和冷漠之间的时间关联值得进一步研究。
Abstract Introduction Apathy is a behavioral syndrome that has been suggested to share similar neuro-physiological pathways with frailty. Objective To investigate the cross-sectional association between apathy and frailty using original data from dementia-free, community-dwelling older adults Method A cross-sectional analysis was performed to test the association between frailty (according to Fried’s frailty phenotype) and apathy (defined by three items from Geriatric Depression Scale) using data from MAPT, a 3-year, randomized, multicenter, placebo-controlled trial among community-dwelling, dementia-free participants (1.679 individuals with mean age of 75 years). Results The ordinal logistic regression showed that apathetic individuals had a two-fold more probability to be rated as frail (OR 2.20, 95% CI 1.7–2.9), when adjusting for confounders. Apathetic individuals display a two-fold more likelihood to be rated as pre-frail (RRR 2.1; 95% CI 1.5–2.8) and a three-fold higher probability to be rated as frail (RRR 3.5, 95% CI 1.8–6.9) compared to robust participants. Conclusion Although data on the associations between apathy and frailty are scarce, these conditions potentially shares physiological mechanisms and were found to be closely associated. Temporal association between frailty and apathy deserve to be further investigated.
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影响因子：
6.6
作者：
Alexopoulos, George S.;Hoptman, Matthew J.;Yuen, Genevieve;Kanellopoulos, Dora;Seirup, Joanna K.;Lim, Kelvin O.;Gunning, Faith M.
通讯作者：
Gunning, Faith M.
影响因子：
--
作者：
B. Vellas;I. Carrié;S. Gillette‐Guyonnet;J. Touchon;T. Dantoine;J. Dartigues;M. Cuffi;S. Bordes;Y. Gasnier;P. Robert;L. Bories;O. Rouaud;F. Desclaux;K. Sudres;M. Bonnefoy;A. Pesce;C. Dufouil;S. Lehéricy;M. Chupin;J. F. Mangin;P. Payoux;D. Adel;P. Legrand;D. Catheline;C. Kanony;M. Zaim;L. Molinier;N. Costa;J. Delrieu;T. Voisin;C. Faisant;F. Lala;F. Nourhashemi;Y. Rolland;G. A. van Kan;C. Dupuy;C. Cantet;P. Cestac;S. Belleville;S. Willis;M. Cesari;M. Weiner;M. Soto;P. Ousset;S. Andrieu
通讯作者：
B. Vellas;I. Carrié;S. Gillette‐Guyonnet;J. Touchon;T. Dantoine;J. Dartigues;M. Cuffi;S. Bordes;Y. Gasnier;P. Robert;L. Bories;O. Rouaud;F. Desclaux;K. Sudres;M. Bonnefoy;A. Pesce;C. Dufouil;S. Lehéricy;M. Chupin;J. F. Mangin;P. Payoux;D. Adel;P. Legrand;D. Catheline;C. Kanony;M. Zaim;L. Molinier;N. Costa;J. Delrieu;T. Voisin;C. Faisant;F. Lala;F. Nourhashemi;Y. Rolland;G. A. van Kan;C. Dupuy;C. Cantet;P. Cestac;S. Belleville;S. Willis;M. Cesari;M. Weiner;M. Soto;P. Ousset;S. Andrieu
使用功能主成分分析对阿尔茨海默病患者的冷漠表型进行分析。
DOI：
10.1016/j.jagp.2012.12.012
发表时间：
2013
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
--
作者：
Zeitzer,JamieM;David,Renaud;Friedman,Leah;Mulin,Emmanuel;Garcia,Rene;Wang,Jia;Yesavage,JeromeA;Robert,PhilippeH;Shannon,William
通讯作者：
Shannon,William
DOI：
10.1093/gerona/56.3.m146
发表时间：
2001-03-01
影响因子：
5.1
作者：
Fried, LP;Tangen, CM;McBurnie, MA
通讯作者：
McBurnie, MA