Insulin resistance as a programmed response to fetal undernutrition
Insulin resistance as a programmed response to fetal undernutrition
复制标题
胰岛素抵抗是对胎儿营养不良的程序性反应
作者：
D. Phillips
组织对胰岛素作用的敏感性受损(胰岛素抵抗)是非胰岛素依赖型糖尿病(NIDDM)的主要异常。胰岛素抵抗也与高血压和血脂异常有关，可能是心脏病的一个重要和可预防的原因[1]。尽管受到年龄、肥胖、缺乏体力活动和某些药物的影响，目前的观点认为胰岛素抵抗是遗传的。然而，最近的证据表明，一种新的假设表明，胰岛素抵抗可能是胎儿对营养不良持续反应的结果。有人提出，营养不良的胎儿进行代谢适应，短期内通过增加燃料供应而受益，但这些适应成为永久性的程序，并持续终生。
Impaired tissue sensitivity to the action of insulin (insulin resistance) is a major abnormality underlying non-insulin-dependent diabetes mellitus (NIDDM). Insulin resistance is also associated with hypertension and dyslipidaemia, and may be an important and preventable cause of heart disease [1]. Although influenced by ageing, obesity, physical inactivity and certain drugs, current opinion holds that insulin resistance is hereditary in origin. Recent evidence, however, suggests a new hypothesis that insulin resistance may occur as a consequence of the persistence of a fetal response to undernutrition. It is suggested that the undernourished fetus makes metabolic adaptations from which it benefits in the short term by increasing fuel availability but that these adaptations become permanently programmed and persist throughout life.
DOI：
10.1016/0169-328x(93)90189-v
发表时间：
1993-05-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
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作者：
PLOTSKY, PM;MEANEY, MJ
通讯作者：
MEANEY, MJ