Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells.
Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells.
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DOI：
10.1172/jci.insight.171806
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发表时间：
2023-09-08
期刊：
影响因子：
8
通讯作者：
Tilburgs, Tamara
中科院分区：
文献类型：
--
作者：
Mahajan, Shweta;Alexander, Aria;Koenig, Zachary;Saba, Nicholas;Prasanphanich, Nina;Hildeman, David A.;Chougnet, Claire A.;Defranco, Emily;Andorf, Sandra;Tilburgs, Tamara
Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. Human decidual CD8+ T cells were shown to be highly differentiated memory T cells with mixed signatures of dysfunction, activation, and effector function. However, no information is present on how specificity for microbial or fetal antigens relates to their function or dysfunction. In addition, a key question, whether decidual CD8+ T cells include unique tissue-resident memory T cells (Trm) or also effector memory T cell (Tem) types shared with peripheral blood populations, is unknown. Here, high-dimensional flow cytometry of decidual and blood CD8+ T cells identified 2 Tem populations shared in blood and decidua and 9 functionally distinct Trm clusters uniquely found in decidua. Interestingly, fetus- and virus-specific decidual CD8+ Trm cells had similar features of inhibition and cytotoxicity, with no significant differences in their expression of activation, inhibitory, and cytotoxic molecules, suggesting that not all fetus-specific CD8+ T cell responses are suppressed at the maternal-fetal interface. Understanding how decidual CD8+ T cell specificity relates to their function and tissue residency is crucial in advancing understanding of their contribution to placental inflammation and control of congenital infections.
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影响因子：
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Becht, Etienne;McInnes, Leland;Newell, Evan W.
通讯作者：
Newell, Evan W.
影响因子：
64.5
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Levine JH;Simonds EF;Bendall SC;Davis KL;Amir el-AD;Tadmor MD;Litvin O;Fienberg HG;Jager A;Zunder ER;Finck R;Gedman AL;Radtke I;Downing JR;Pe'er D;Nolan GP
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Nolan GP
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Nowicka, Malgorzata;Krieg, Carsten;Robinson, Mark D
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Robinson, Mark D
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Chougnet, Claire A.;Tripathi, Pulak;Hildeman, David A.
通讯作者：
Hildeman, David A.
影响因子：
3.4
作者：
Crespo ÂC;van der Zwan A;Ramalho-Santos J;Strominger JL;Tilburgs T
通讯作者：
Tilburgs T