Progress in treatment of type 2 diabetes by bariatric surgery.
Progress in treatment of type 2 diabetes by bariatric surgery.
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DOI：
10.4239/wjd.v12.i8.1187
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发表时间：
2021-08-15
影响因子：
4.2
通讯作者：
Liu W
中科院分区：
文献类型：
--
作者：
Jin ZL;Liu W
2型糖尿病（T2D）的发病率在世界范围内以惊人的速度增长。减肥外科手术，如垂直袖胃切除术和Roux-en-Y胃旁路术，是获得实质性和持久的T2D缓解的最有效方法。减肥手术的好处是通过增加饱腹感和胃肠道激素、胆汁酸和肠道微生物群的改变来实现的。全面了解各种减肥手术对T2D的作用机制有助于设计更好的T2D非手术治疗方法。在这篇综述中，我们描述了减肥手术的分类和发展，并探讨了减肥手术对胰岛素抵抗影响的多种机制。基于我们对潜在机制的现有知识的总结，我们推测肠道可能作为改善T2D的新靶点。本综述的最终目的是更好地了解T2D的病理生理学，以支持开发侵入性更小、可扩展的T2D治疗方法。
The incidence of type 2 diabetes (T2D) is increasing at an alarming rate worldwide. Bariatric surgical procedures, such as the vertical sleeve gastrectomy and Roux-en-Y gastric bypass, are the most efficient approaches to obtain substantial and durable remission of T2D. The benefits of bariatric surgery are realized through the consequent increased satiety and alterations in gastrointestinal hormones, bile acids, and the intestinal microbiota. A comprehensive understanding of the mechanisms by which various bariatric surgical procedures exert their benefits on T2D could contribute to the design of better non-surgical treatments for T2D. In this review, we describe the classification and evolution of bariatric surgery and explore the multiple mechanisms underlying the effect of bariatric surgery on insulin resistance. Based upon our summarization of the current knowledge on the underlying mechanisms, we speculate that the gut might act as a new target for improving T2D. Our ultimate goal with this review is to provide a better understanding of T2D pathophysiology in order to support development of T2D treatments that are less invasive and more scalable.
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影响因子：
8.2
作者：
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