A Systematic Review and Meta-Analysis of Hospitalised Current Smokers and COVID-19.
A Systematic Review and Meta-Analysis of Hospitalised Current Smokers and COVID-19.
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DOI：
10.3390/ijerph17207394
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发表时间：
2020-10-11
影响因子：
--
通讯作者：
Nájera A
中科院分区：
文献类型：
--
作者：
González-Rubio J;Navarro-López C;López-Nájera E;López-Nájera A;Jiménez-Díaz L;Navarro-López JD;Nájera A
SARS-CoV-2是一种新的冠状病毒，已导致全球大流行。它产生严重急性呼吸道疾病（COVID-19），在许多情况下是致命的，其特征是细胞因子释放综合征（CRS）。根据世界卫生组织的数据，吸烟者可能更容易受到感染。在这里，为了阐明吸烟与COVID-19之间的流行病学关系，我们提出了一项系统性文献综述（截至2020年4月28日）和一项荟萃分析。我们纳入了来自中国、美国和意大利的720项初始研究的18项基于吸烟患者状态的近期COVID-19临床和流行病学研究。中国、美国和意大利的住院当前吸烟者百分比分别为7.7%（95% CI：6.9-8.4）、2.3%（95% CI：1.7-2.9）和7.6%（95% CI：4.2-11.0）。将这些百分比与每个国家的吸烟流行率进行比较，发现所有这些百分比在统计学上都有显著差异（p < 0.0001）。通过荟萃分析，我们提供的流行病学证据显示，吸烟者住院的可能性在统计学上较低（OR = 0.18，95%CI：0.14-0.23，p < 0.01）。总之，对18项研究数据的分析显示，目前吸烟者住院的比例比预期低得多。随着更多研究的出现，应检查这一趋势，以获得结论性结果，并在适当情况下探索COVID-19严重进展和不良结局的潜在机制。
SARS-CoV-2 is a new coronavirus that has caused a worldwide pandemic. It produces severe acute respiratory disease (COVID-19), which is fatal in many cases, characterised by the cytokine release syndrome (CRS). According to the World Health Organization, those who smoke are likely to be more vulnerable to infection. Here, in order to clarify the epidemiologic relationship between smoking and COVID-19, we present a systematic literature review until 28th April 2020 and a meta-analysis. We included 18 recent COVID-19 clinical and epidemiological studies based on smoking patient status from 720 initial studies in China, the USA, and Italy. The percentage of hospitalised current smokers was 7.7% (95% CI: 6.9–8.4) in China, 2.3% (95% CI: 1.7–2.9) in the USA and 7.6% (95% CI: 4.2–11.0) in Italy. These percentages were compared to the smoking prevalence of each country and statistically significant differences were found in them all (p < 0.0001). By means of the meta-analysis, we offer epidemiological evidence showing that smokers were statistically less likely to be hospitalised (OR = 0.18, 95% CI: 0.14–0.23, p < 0.01). In conclusion, the analysis of data from 18 studies shows a much lower percentage of hospitalised current smokers than expected. As more studies become available, this trend should be checked to obtain conclusive results and to explore, where appropriate, the underlying mechanism of the severe progression and adverse outcomes of COVID-19.
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影响因子：
3.7
作者：
Carroll HA;Toumpakari Z;Johnson L;Betts JA
通讯作者：
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