Predictors of distress in female breast cancer survivors: a systematic review.
Predictors of distress in female breast cancer survivors: a systematic review.
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DOI：
10.1007/s10549-017-4290-9
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发表时间：
2017-09
影响因子：
3.8
通讯作者：
Tamblyn R
中科院分区：
文献类型：
--
作者：
Syrowatka A;Motulsky A;Kurteva S;Hanley JA;Dixon WG;Meguerditchian AN;Tamblyn R
未经管理的痛苦已被证明会对乳腺癌幸存者的生存和生活质量产生不利影响。幸运的是，通过适当的循证干预措施可以控制甚至预防痛苦。因此，本系统综述的目的是综合已发表的有关女性乳腺癌幸存者痛苦预测因素的文献，以帮助指导有针对性的干预措施，以预防痛苦。通过搜索 MEDLINE、Embase、PsycINFO 和 CINAHL 数据库找到相关研究。描述性地总结了常用评估的候选预测因子 (n ≥ 5) 和至少两项研究显示显着的预测因子 (p ≤ 0.05) 之间关联的显着性和方向性。根据显示与痛苦存在显着且正相关的研究比例来评估预测因素。 42 项研究符合目标标准并被纳入审查。乳腺癌和治疗相关的预测因素包括诊断时的晚期癌症、化疗治疗、较长的主要治疗持续时间、最近的生存期以及乳腺癌复发。与痛苦相关的可控制的治疗相关症状包括更年期/血管舒缩症状、疼痛、疲劳和睡眠障碍。增加痛苦风险的社会人口特征包括年龄较小、非白人、未婚和社会经济地位较低。合并症、心理健康问题史和感知的功能限制也相关。痛苦的可修改预测因素是较低的体力活动、较低的社会支持和吸烟。该综述建立了一套基于证据的预测因素，可用于帮助识别在完成乳腺癌初级治疗后经历痛苦的较高风险的女性。本文的在线版本 (doi:10.1007/s10549-017-4290-9) 包含补充材料，可供授权用户使用。
Unmanaged distress has been shown to adversely affect survival and quality of life in breast cancer survivors. Fortunately, distress can be managed and even prevented with appropriate evidence-based interventions. Therefore, the objective of this systematic review was to synthesize the published literature around predictors of distress in female breast cancer survivors to help guide targeted intervention to prevent distress. Relevant studies were located by searching MEDLINE, Embase, PsycINFO, and CINAHL databases. Significance and directionality of associations for commonly assessed candidate predictors (n ≥ 5) and predictors shown to be significant (p ≤ 0.05) by at least two studies were summarized descriptively. Predictors were evaluated based on the proportion of studies that showed a significant and positive association with the presence of distress. Forty-two studies met the target criteria and were included in the review. Breast cancer and treatment-related predictors were more advanced cancer at diagnosis, treatment with chemotherapy, longer primary treatment duration, more recent transition into survivorship, and breast cancer recurrence. Manageable treatment-related symptoms associated with distress included menopausal/vasomotor symptoms, pain, fatigue, and sleep disturbance. Sociodemographic characteristics that increased the risk of distress were younger age, non-Caucasian ethnicity, being unmarried, and lower socioeconomic status. Comorbidities, history of mental health problems, and perceived functioning limitations were also associated. Modifiable predictors of distress were lower physical activity, lower social support, and cigarette smoking. This review established a set of evidence-based predictors that can be used to help identify women at higher risk of experiencing distress following completion of primary breast cancer treatment. The online version of this article (doi:10.1007/s10549-017-4290-9) contains supplementary material, which is available to authorized users.
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