Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder.
Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder.
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DOI：
10.1016/j.conb.2011.10.016
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发表时间：
2011-12
影响因子：
5.7
通讯作者：
Lu B
中科院分区：
文献类型：
--
作者：
Imai Y;Lu B
帕金森病（PD）是最常见的运动障碍，其特征是中脑黑质多巴胺能神经元的年龄依赖性变性。然而，PD的非运动症状先于多巴胺能系统功能障碍引起的运动特征，表明PD是一种全身性疾病。在PD患者和动物模型中长期观察到线粒体功能障碍，但线粒体功能障碍与PD发病机制之间的机制联系尚不清楚。最近的研究表明，与常染色体隐性形式的PD相关的基因如PINK1和Parkin直接参与调节线粒体形态和维持，其异常也在更常见的散发性形式的PD中观察到，尽管常染色体隐性PD缺乏散发性PD的特征性路易体病理。这些最新的发现表明，至少某些形式的PD可以被表征为线粒体疾病。线粒体功能障碍是否代表所有PD病例的统一致病机制仍然是一个尚未解决的主要问题。
Parkinson’s disease (PD), the most common movement disorder, is characterized by age-dependent degeneration of dopaminergic neurons in the substantia nigra of the mid-brain. Non-motor symptoms of PD, however, precede the motor features caused by dysfunction of the dopaminergic system, suggesting that PD is a systemic disorder. Mitochondrial dysfunction has long been observed in PD patients and animal models, but the mechanistic link between mitochondrial dysfunction and PD pathogenesis is not well understood. Recent studies have revealed that genes associated with autosomal recessive forms of PD such as PINK1 and Parkin are directly involved in regulating mitochondrial morphology and maintenance, abnormality of which is also observed in the more common, sporadic forms of PD, although the autosomal recessive PDs lack Lewy-body pathology that is characteristic of sporadic PD. These latest findings suggest that at least some forms of PD can be characterized as a mitochondrial disorder. Whether mitochondrial dysfunction represents a unifying pathogenic mechanism of all PD cases remains a major unresolved question.
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影响因子：
4.5
作者：
Imai Y;Kanao T;Sawada T;Kobayashi Y;Moriwaki Y;Ishida Y;Takeda K;Ichijo H;Lu B;Takahashi R
通讯作者：
Takahashi R
DOI：
10.1083/jcb.201008084
发表时间：
2010-11-29
期刊：
The Journal of cell biology
影响因子：
--
作者：
Jin SM;Lazarou M;Wang C;Kane LA;Narendra DP;Youle RJ
通讯作者：
Youle RJ
影响因子：
3.7
作者：
Huang C;Andres AM;Ratliff EP;Hernandez G;Lee P;Gottlieb RA
通讯作者：
Gottlieb RA
DOI：
10.1073/pnas.0911175107
发表时间：
2010-05-25
影响因子：
11.1
作者：
Hao, Ling-Yang;Giasson, Benoit I.;Bonini, Nancy M.
通讯作者：
Bonini, Nancy M.
ATG32是一种线粒体蛋白，在线粒体过程中赋予了选择性。
影响因子：
11.8
作者：
Kanki, Tomotake;Wang, Ke;Cao, Yang;Baba, Misuzu;Klionsky, Daniel J.
通讯作者：
Klionsky, Daniel J.