Self-assembling peptides as immunomodulatory biomaterials.

Self-assembling peptides as immunomodulatory biomaterials.
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自组装肽作为免疫调节生物材料。

DOI:
10.3389/fbioe.2023.1139782
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发表时间:
2023
影响因子:
5.7
通讯作者:
Young, Simon
Young, Simon
中科院分区:
工程技术2区
文献类型:
--
作者:
Hernandez, Andrea;Hartgerink, Jeffrey D. D.;Young, Simon

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自组装肽是一种在生物医学和材料科学领域迅速兴起的生物材料,具有良好的生物相容性和控释效果。这些自组装肽可以在分子相互作用的作用下形成不同的纳米结构,使它们成为多功能材料。一旦组装起来,这些多肽就可以模拟生物功能,并提供细胞因子和药物等治疗药物的组合输送。这些自组装肽在生物医学环境中显示出成功,但面临着独特的挑战,必须解决这些挑战才能在临床上广泛应用。在此,我们描述了自组装肽的特性及其在免疫调节治疗中的应用现状。
Self-assembling peptides are a type of biomaterial rapidly emerging in the fields of biomedicine and material sciences due to their promise in biocompatibility and effectiveness at controlled release. These self-assembling peptides can form diverse nanostructures in response to molecular interactions, making them versatile materials. Once assembled, the peptides can mimic biological functions and provide a combinatorial delivery of therapeutics such as cytokines and drugs. These self-assembling peptides are showing success in biomedical settings yet face unique challenges that must be addressed to be widely applied in the clinic. Herein, we describe self-assembling peptides’ characteristics and current applications in immunomodulatory therapeutics.
DOI: 10.3389/fbinf.2022.1046493
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影响因子: --
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