Tripartite Mechanism of Neural Memory: Proof-of-Concept with Neuromimetic Impedence Electrodes
Tripartite Mechanism of Neural Memory: Proof-of-Concept with Neuromimetic Impedence Electrodes
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神经记忆的三重机制：模拟神经阻抗电极的概念验证
DOI：
10.31579/2692-9406/021
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
C. Gilon
中科院分区：
文献类型：
--
作者：
Gerard Marx;C. Gilon
神经信号是心理过程的基础这一观点由来已久。我们以图形方式总结了信号传导的神经生物学的显著发展，作为一个时间轴。特别是，我们审查的“三方机制”的神经记忆，它的中心与周围的细胞外基质（nECM）掺杂金属和神经递质（NT）的神经元之间的相互作用。本质上，神经元采用nECM作为其“记忆材料”，其中它使用掺杂剂来编码信息的认知单元（称为“cuinfo”）。神经网络引发身体反应（感觉），也将过去的感觉编码为情绪，这些情绪在实时和记忆中“着色”精神状态。为了开发三方机制的实验测试，阻抗玻璃电极共价涂覆有示例性NT（催产素）或nECM的硫酸化四糖类似物，构建并测试。这两种类型的涂层神经模拟电极，称为“neulectrodes”，能够检测金属，如Hg+2，Pb+2，Cd+2，Cu+2和Zn+2，具有非常高的选择性和灵敏度。“神经电极”表明，金属阳离子与NT或nECM-糖类似物的化学动力学相互作用可以转化为电动信号。他们通过实验验证了神经记忆化学电编码的三重机制的概念。
The idea that neural signaling is the basis of mental processes has a long history. We graphically summarize salient developments in the neurobiology of signaling, as a Timeline. In particular, we review the “tripartite mechanism” of neural memory, which centers on the interactions between a neuron with its surrounding extracellular matrix (nECM) doped with metals and neurotransmitters (NTs). Essentially, the neuron employs the nECM as its “memory material”, wherein it uses dopants to encode cognitive units of information (termed “cuinfo”). The NTs, which elicit bodily reactions (feelings), also encode past feelings as emotions, which “color” mental states in real-time and in memory. In the interest of developing experimental tests of the tripartite mechanism, impedance glass electrodes were covalently coated with an exemplar NT (oxytocin) or a sulfated tetra-saccharide analog of the nECM, were constructed and tested. The two types of coated, neuro-mimetic electrodes, termed “neulectrodes”, were capable of detecting metals, such as Hg+2, Pb+2, Cd+2, Cu+2, and Zn+2 with very high selectivity and sensitivity. The “neulectrodes” demonstrated that the chemodynamic interactions of metal cations with NTs or nECM-saccharide analogues can translate into electrodynamic signals. They experimentally validate the concept of the tripartite mechanism that underlies the chemo-electric encoding of neural memory.
DOI：
10.1126/science.aaf3627
发表时间：
2017-05-05
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Zhang YS;Khademhosseini A
通讯作者：
Khademhosseini A