Advances in engineering hydrogels.
Advances in engineering hydrogels.
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DOI：
10.1126/science.aaf3627
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发表时间：
2017-05-05
期刊：
影响因子：
--
通讯作者：
Khademhosseini A
中科院分区：
文献类型：
--
作者：
Zhang YS;Khademhosseini A
水凝胶是由亲水性聚合物链包围在富水环境中形成的。它们在生物医学、软电子、传感器和执行器等各个领域有着广泛的应用。传统的水凝胶通常具有有限的机械强度，并且容易永久断裂。此外，水凝胶中缺乏动态线索和结构复杂性限制了它们的功能。最近的发展包括具有改进的物理化学性质的工程水凝胶，从创新的化学和成分设计到动态调制和复杂结构的集成。我们回顾了水凝胶设计和工程的主要进展，以及在多个尺度上精确操纵其性质的策略。在改善水凝胶的力学性能以及使其剪切变薄、自愈和响应方面取得了进展。此外，已经开发了技术来操纵水凝胶的形状、结构和结构，以增强控制和空间精度。
Hydrogels are formed from hydrophilic polymer chains surrounded by a water-rich environment. They have widespread applications in various fields such as biomedicine, soft electronics, sensors, and actuators. Conventional hydrogels usually possess limited mechanical strength and are prone to permanent breakage. Further, the lack of dynamic cues and structural complexity within the hydrogels has limited their functions. Recent developments include engineering hydrogels that possess improved physicochemical properties, ranging from designs of innovative chemistries and compositions to integration of dynamic modulation and sophisticated architectures. We review major advances in designing and engineering hydrogels and strategies targeting precise manipulation of their properties across multiple scales. Advances have been made to improve the mechanical properties of hydrogels as well as to make them shear-thinning, self-healing, and responsive. In addition, technologies have been developed to manipulate the shape, structure, and architecture of hydrogels with enhanced control and spatial precision.
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影响因子：
56.9
作者：
Chworos, A;Severcan, I;Jaeger, L
通讯作者：
Jaeger, L
影响因子：
16.6
作者：
Appel EA;Tibbitt MW;Webber MJ;Mattix BA;Veiseh O;Langer R
通讯作者：
Langer R
影响因子：
14
作者：
Bodugoz-Senturk, Hatice;Macias, Celia E.;Muratoglu, Orhun K.
通讯作者：
Muratoglu, Orhun K.
影响因子：
16.6
作者：
Bin Imran A;Esaki K;Gotoh H;Seki T;Ito K;Sakai Y;Takeoka Y
通讯作者：
Takeoka Y
DOI：
10.1002/adma.201503255
发表时间：
2016-01-06
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Annabi N;Shin SR;Tamayol A;Miscuglio M;Bakooshli MA;Assmann A;Mostafalu P;Sun JY;Mithieux S;Cheung L;Tang XS;Weiss AS;Khademhosseini A
通讯作者：
Khademhosseini A