Impaired reward learning and intact motivation after serotonin depletion in rats.
Impaired reward learning and intact motivation after serotonin depletion in rats.
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DOI：
10.1016/j.bbr.2012.05.032
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发表时间：
2012-08-01
影响因子：
2.7
通讯作者：
Zhou, Feimeng
中科院分区：
文献类型：
--
作者：
Izquierdo, Alicia;Carlos, Kathleen;Ostrander, Serena;Rodriguez, Danilo;McCall-Craddolph, Aaron;Yagnik, Gargey;Zhou, Feimeng
Aside from the well-known influence of serotonin (5-hydroxytryptamine, 5-HT) on emotional regulation, more recent investigations have revealed the importance of this monoamine in modulating cognition. Parachlorophenylalanine (PCPA) depletes 5-HT by inhibiting tryptophan hydroxylase, the enzyme required for 5-HT synthesis and, if administered at sufficiently high doses, can result in a depletion of at least 90% of the brain s 5-HT levels. The present study assessed the long-lasting effects of widespread 5-HT depletions on two tasks of cognitive flexibility in Long Evans rats: effort discounting and reversal learning. We assessed performance on these tasks after administration of either 250 or 500 mg/kg PCPA or saline (SAL) on two consecutive days. Consistent with a previous report investigating the role of 5-HT on effort discounting, pretreatment with either dose of PCPA resulted in normal effortful choice: All rats continued to climb tall barriers to obtain large rewards and were not work-averse. Additionally, rats receiving the lower dose of PCPA displayed normal reversal learning. However, despite intact motivation to work for food rewards, rats receiving the largest dose of PCPA were unexpectedly impaired relative to SAL rats on the pretraining stages leading up to reversal learning, ultimately failing to approach and respond to the stimuli associated with reward. High performance liquid chromatography (HPLC) with electrochemical detection confirmed 5-HT, and not dopamine, levels in the ventromedial frontal cortex were correlated with this measure of associative reward learning.
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影响因子：
3.4
作者：
Izquierdo, Alicia;Jentsch, J. David
通讯作者：
Jentsch, J. David
大鼠暴食甲基苯丙胺后逆转特异性学习障碍：可能涉及纹状体多巴胺。
影响因子：
7.6
作者：
Izquierdo, Alicia;Belcher, Annabelle M.;Scott, Lori;Cazares, Victor A.;Chen, Jack;O'Dell, Steven J.;Malvaez, Melissa;Wu, Tiffany;Marshall, John F.
通讯作者：
Marshall, John F.
影响因子：
3.7
作者：
Clarke, H. F.;Walker, S. C.;Roberts, A. C.
通讯作者：
Roberts, A. C.
影响因子：
3.4
作者：
Harrison, AA;Everitt, BJ;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
3.4
作者：
Lapiz-Bluhm, M. Danet S.;Soto-Pina, Alexandra E.;Morilak, David A.
通讯作者：
Morilak, David A.