Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.
Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.
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DOI：
10.1002/nbm.3005
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发表时间：
2013-12
影响因子：
2.9
通讯作者：
Brindle, Kevin M.
中科院分区：
文献类型：
--
作者：
Marco-Rius, Irene;Tayler, Michael C. D.;Kettunen, Mikko I.;Larkin, Timothy J.;Timm, Kerstin N.;Serrao, Eva M.;Rodrigues, Tiago B.;Pileio, Giuseppe;Ardenkjaer-Larsen, Jan Henrik;Levitt, Malcolm H.;Brindle, Kevin M.
关键词：
超极化核磁共振是一种很有前途的无创成像技术的组织代谢在体内。然而，可以研究的途径受到核自旋序的快速T1衰变的限制。在含有成对的耦合核自旋-1/2的代谢物中，可以通过利用成对的非磁性单线态（自旋-0）来维持自旋顺序。这可以允许在运输到感兴趣的组织（例如肿瘤）期间在体内保持超极化，或者检测较慢的代谢反应。我们在这里表明，在人体血液和小鼠体内在毫特斯拉领域的[1，2 - 13 C2]丙酮酸的13 C单线态寿命显着长于13 C T1，虽然它是短于T1在几个特斯拉的场强。我们还检查了观察到的超极化[1，2 - 13 C2]乳酸盐的单线态衍生的NMR光谱，其源自[1，2 - 13 C2]丙酮酸盐的代谢。© 2013作者。NMR in Biomedicine，John Wiley & Sons，Ltd.
Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained by exploiting the non-magnetic singlet (spin-0) state of the pair. This may allow preservation of the hyperpolarization in vivo during transport to tissues of interest, such as tumors, or to detect slower metabolic reactions. We show here that in human blood and in a mouse in vivo at millitesla fields the 13C singlet lifetime of [1,2-13C2]pyruvate was significantly longer than the 13C T1, although it was shorter than the T1 at field strengths of several tesla. We also examine the singlet-derived NMR spectrum observed for hyperpolarized [1,2-13C2]lactate, originating from the metabolism of [1,2-13C2]pyruvate. © 2013 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd.
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影响因子：
3.3
作者：
Silvennoinen, MJ;Kettunen, MI;Kauppinen, RA
通讯作者：
Kauppinen, RA
DOI：
10.1073/pnas.1010570107
发表时间：
2010-10-05
影响因子：
11.1
作者：
Pileio, Giuseppe;Carravetta, Marina;Levitt, Malcolm H.
通讯作者：
Levitt, Malcolm H.
影响因子：
2.8
作者：
Bornet, Aurelien;Jannin, Sami;Bodenhausen, Geoffrey
通讯作者：
Bodenhausen, Geoffrey
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
4.8
作者：
Witney, Timothy H.;Kettunen, Mikko I.;Brindle, Kevin M.
通讯作者：
Brindle, Kevin M.