Aggregation of Urinary Microcrystallines with Different Sizes

Aggregation of Urinary Microcrystallines with Different Sizes
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不同尺寸尿液微晶的聚集

DOI:
10.3724/sp.j.1077.2012.00343
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发表时间:
2012
影响因子:
1.7
通讯作者:
Ouyang Jian-Ming
Ouyang Jian-Ming
中科院分区:
材料科学4区
文献类型:
--
作者:
He Jie-Yu;Yang Jin;Hou Shan-Hua;Ouyang Jian-Ming

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应用透射电镜(TEM)和纳米颗粒分析仪,比较研究了草酸钙(CaOxa)结石患者和健康对照者尿中微晶的平均粒径(d)、自相关曲线、聚集状态和稳定性随放置时间的变化。尿液样品分别用孔径为0.22、0.45、1.2和3 μm的微孔滤膜过滤。随着放置时间从0 ~ 4 h的增加,患者各种尿液中的微晶d值迅速增加。放置4 h后,d(Δ d)分别为1439、1557、1534和1051 nm。而对照组尿中微晶的Δ d相对较小,分别为474、511、567和433 nm。与对照组相比,患者尿中的微粒聚集快、量大,稳定性差。尿中小颗粒比大颗粒更容易聚集。结果表明,尿中微晶的快速凝聚可能在CaOxa结石的形成中起重要作用。
Changes of average size ( d ), autocorrelation curve, aggregation state and stability of urinary crystallites in urine samples of calcium oxalate (CaOxa) stone patients and healthy controls with placement time were com- paratively studied using transmission electron microscopy (TEM) and nanoparticle size analyzer. The urine samples were filtrated by microporous membrane with a pore size of 0.22, 0.45, 1.2 and 3 μm, respectively. With the in- crease of placement time from 0 to 4 h, the d values of the crystallites in various filtrated urine of patients in- creased rapidly. The amplification of d (Δ d ) was 1439, 1557, 1534 and 1051 nm, respectively, when the place- ment time was up to 4 h. However, the Δ d of the urine crystallites of the controls was relatively small, which was only 474, 511, 567 and 433 nm, respectively. The urinary crystallites of the patients had rapid and large agglomera- tion and poor stability compared with those of the controls. The urinary crystallites of small size agglomerated more easily than those of large size. The results show that the rapid agglomeration of urine crystallites may play an im- portant role in the formation of CaOxa stones.
DOI: --
发表时间: 1978-05
期刊: Investigative urology
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