The Research Progress in Transforming Growth Factor-β2.
The Research Progress in Transforming Growth Factor-β2.
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DOI：
10.3390/cells12232739
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发表时间：
2023-11-30
期刊：
影响因子：
6
通讯作者：
Liu, Jie
中科院分区：
文献类型：
--
作者：
Wang, Meng-Yan;Liu, Wen-Juan;Wu, Le-Yi;Wang, Gang;Zhang, Cheng-Lin;Liu, Jie
转化生长因子-β 2（Transforming growth factor-beta 2，TGF-β2）是TGF-β家族的重要成员，是一种分泌性蛋白，参与细胞生长、增殖、迁移和分化等多种生物学过程。TGF-β2被认为与TGF-β1在功能上相同;然而，越来越多的研究揭示了TGF-β2在表达、活化和生物学功能方面的独特特征。TGF-β2缺乏的小鼠表现出多个器官的显著发育异常，尤其是心血管系统。TGF-β2信号转导失调与肿瘤发生、眼部疾病、心血管疾病、免疫紊乱以及运动系统疾病相关。本文就TGF-β2的研究进展作一综述，以期为TGF-β2的进一步研究提供参考。
Transforming growth factor-beta 2 (TGF-β2), an important member of the TGF-β family, is a secreted protein that is involved in many biological processes, such as cell growth, proliferation, migration, and differentiation. TGF-β2 had been thought to be functionally identical to TGF-β1; however, an increasing number of recent studies uncovered the distinctive features of TGF-β2 in terms of its expression, activation, and biological functions. Mice deficient in TGF-β2 showed remarkable developmental abnormalities in multiple organs, especially the cardiovascular system. Dysregulation of TGF-β2 signalling was associated with tumorigenesis, eye diseases, cardiovascular diseases, immune disorders, as well as motor system diseases. Here, we provide a comprehensive review of the research progress in TGF-β2 to support further research on TGF-β2.
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