Internalization of Salmonella by macrophages induces formation of nonreplicating persisters.
Internalization of Salmonella by macrophages induces formation of nonreplicating persisters.
复制标题
通过巨噬细胞对沙门氏菌的内在化会导致形成非复制的持久性。
DOI：
10.1126/science.1244705
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发表时间：
2014-01-10
期刊：
影响因子：
--
通讯作者：
Holden DW
中科院分区：
文献类型：
--
作者：
Helaine S;Cheverton AM;Watson KG;Faure LM;Matthews SA;Holden DW
许多细菌病原体会导致持续的抗生素持续性持续性。感染期间的持久性是巨噬细胞在吸收后立即形成的不复制人群的一部分酸化和营养剥夺，也诱导14个毒素 - 抗毒素模块的沙门氏菌基因表达。细菌复制或形成非复制的持久者，可以为感染带来储层。
Many bacterial pathogens cause persistent infections despite repeated antibiotic exposure. Bacterial persisters are antibiotic-tolerant cells, but little is known about their growth status and the signals and pathways leading to their formation in infected tissues. We used fluorescent single-cell analysis to identify Salmonella persisters during infection. These were part of a nonreplicating population formed immediately after uptake by macrophages and were induced by vacuolar acidification and nutritional deprivation, conditions that also induce Salmonella virulence gene expression. The majority of 14 toxin-antitoxin modules contributed to intracellular persister formation. Some persisters resumed intracellular growth after phagocytosis by naïve macrophages. Thus, the vacuolar environment induces phenotypic heterogeneity, leading to either bacterial replication or the formation of nonreplicating persisters that could provide a reservoir for relapsing infection.
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影响因子：
14.9
作者：
Shao Y;Harrison EM;Bi D;Tai C;He X;Ou HY;Rajakumar K;Deng Z
通讯作者：
Deng Z
由巨噬细胞诱导的外排机制介导的复制分枝杆菌的药物耐受性。
影响因子：
64.5
作者：
Adams KN;Takaki K;Connolly LE;Wiedenhoft H;Winglee K;Humbert O;Edelstein PH;Cosma CL;Ramakrishnan L
通讯作者：
Ramakrishnan L
DOI：
10.1073/pnas.1000041107
发表时间：
2010-02-23
影响因子：
11.1
作者：
Helaine, Sophie;Thompson, Jessica A.;Holden, David W.
通讯作者：
Holden, David W.
影响因子：
64.5
作者：
Maisonneuve, Etienne;Castro-Camargo, Manuela;Gerdes, Kenn
通讯作者：
Gerdes, Kenn
影响因子：
6.7
作者：
Steeb B;Claudi B;Burton NA;Tienz P;Schmidt A;Farhan H;Mazé A;Bumann D
通讯作者：
Bumann D