Brain extracellular matrix in neurodegeneration.

Brain extracellular matrix in neurodegeneration.
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DOI:
10.1111/j.1750-3639.2008.00195.x
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发表时间:
2009-10
期刊:
Brain pathology (Zurich, Switzerland)
影响因子:
--
通讯作者:
Wiley CA
Wiley CA
中科院分区:
其他
文献类型:
--
作者:
Bonneh-Barkay D;Wiley CA

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细胞外基质(ECM)在神经系统发育、功能和变性中的作用已从简单的物理粘附演变为复杂的细胞信号传导系统。虽然大多数细胞需要ECM粘附才能生存,但现在清楚的是,分化功能密切依赖于细胞与ECM的相互作用。因此,越来越多地发现ECM参与神经变性的神秘过程并不奇怪。人类神经退行性疾病的描述性研究和神经退行性疾病动物模型的实验研究已经开始定义ECM破坏的潜在机制,其可导致突触和神经元损失。
The role of extracellular matrix (ECM) in neurological development, function and degeneration has evolved from a simplistic physical adhesion to a system of intricate cellular signaling. While most cells require ECM adhesion to survive, it is now clear that differentiated function is intimately dependent upon cellular interaction with the ECM. Therefore, it is not surprising that the ECM is increasingly found to be involved in the enigmatic process of neurodegeneration. Descriptive studies of human neurodegenerative disorders and experimental studies of animal models of neurodegeneration have begun to define potential mechanisms of ECM disruption that can lead to synaptic and neuronal loss.
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