Idiopathic nephrotic syndrome and atopy: is there a common link?
Idiopathic nephrotic syndrome and atopy: is there a common link?
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DOI：
10.1053/j.ajkd.2009.03.019
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Garin EH
中科院分区：
文献类型：
--
作者：
Abdel-Hafez M;Shimada M;Lee PY;Johnson RJ;Garin EH
过去 60 年的大量报告表明特发性肾病综合征与特应性疾病之间存在密切关联。过敏反应可引发特发性肾病综合征，并且与空气过敏原（花粉、霉菌和灰尘）和食物过敏有关。特发性肾病综合征患者也可能表现出血清免疫球蛋白 E (IgE) 水平升高。文献综述表明，尽管一些特发性肾病综合征病例可能与过敏有关，但表明它是一种过敏性疾病或可由特定过敏原诱发的证据薄弱。相反，特发性肾病综合征患者的蛋白尿和 IgE 水平升高很可能是由在这些患者中观察到的白细胞介素 13 水平升高引起的。最近的研究表明，白细胞介素 13（一种已知的 IgE 反应刺激剂）可能会介导微小病变患者的蛋白尿，因为它能够直接诱导足细胞上的 CD80 表达。
Numerous reports during the last 60 years have reported a strong association between idiopathic nephrotic syndrome and atopic disorders. Idiopathic nephrotic syndrome can be precipitated by allergic reactions and has been associated with both aeroallergens (pollens, mold, and dust) and food allergies. Patients with idiopathic nephrotic syndrome also may show increased serum immunoglobulin E (IgE) levels. A review of the literature suggests that although some idiopathic nephrotic syndrome cases may be associated with allergies, evidence that it is a type of allergic disorder or can be induced by a specific allergen is weak. Rather, it is likely that the proteinuria and increased IgE levels in patients with idiopathic nephrotic syndrome are caused by increased levels of interleukin 13 observed in these patients. Recent studies suggest that interleukin 13, a known stimulator of IgE response, may mediate proteinuria in patients with minimal change disease because of its ability to directly induce CD80 expression on the podocyte.
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