Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism.
Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism.
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DOI：
10.1001/jamaneurol.2013.1878
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发表时间：
2013-08
期刊：
影响因子：
29
通讯作者：
Jagust, William J.
中科院分区：
文献类型：
--
作者：
Haight, Thaddeus J.;Landau, Susan M.;Carmichael, Owen;Schwarz, Christopher;DeCarli, Charles;Jagust, William J.
脑血管疾病和阿尔茨海默病（AD）经常同时发生，并且似乎通过不同的途径产生痴呆症。探讨轻度认知功能障碍患者脑血管病和AD标志物与脑葡萄糖代谢的关系。美国和加拿大阿尔茨海默病神经影像学倡议临床研究中心的队列研究。在3年随访期内，203例患有遗忘性轻度认知障碍（其中74例转化为AD）的患者进行了系列成像。量化的白色高信号（WMH）代表脑血管疾病，脑脊液β-淀粉样蛋白代表AD病理学。使用氟脱氧葡萄糖F18的正电子发射断层扫描测量颞顶和额叶脑区的脑葡萄糖代谢。在转换者中，更大的WMH与额叶代谢减少相关（-0.048; 95%CI，-0.067至0.029），但与颞顶代谢无关（0.010; 95%CI，-0.010至0.030）。在相同患者中，脑脊液β-淀粉样蛋白（每增加10 pg/mL）增加与颞顶代谢增加相关（0.005; 95% CI，0.000-0.010），但与额叶代谢无关（0.002; 95% CI，-0.004至0.007）。在非转换者中，观察到类似的关系，除了更大的WMH与颞顶代谢增加呈正相关（0.051; 95%CI，0.027-0.076）。与局部葡萄糖代谢相关的WMH和脑脊液β-淀粉样蛋白的解离表明，这些病理状况在AD中通过反映不同脑系统功能障碍的不同且独立的途径起作用。更大的WMH与颞顶代谢的正相关性表明，这些病理过程不同时发生在nonconverters。
Cerebrovascular disease and Alzheimer disease (AD) frequently co-occur and seem to act through different pathways in producing dementia. To examine cerebrovascular disease and AD markers in relation to brain glucose metabolism in patients with mild cognitive impairment. Cohort study among the Alzheimer Disease Neuroimaging Initiative clinical sites in the United States and Canada. Two hundred three patients having amnestic mild cognitive impairment (74 of whom converted to AD) with serial imaging during a 3-year follow-up period. Quantified white matter hyperintensities (WMHs) represented cerebrovascular disease, and cerebrospinal fluid β-amyloid represented AD pathology. Brain glucose metabolism in temporoparietal and frontal brain regions was measured using positron emission tomography with fluorodeoxyglucose F18. In converters, greater WMHs were associated with decreased frontal metabolism (−0.048; 95% CI, −0.067 to −0.029) but not temporoparietal metabolism (0.010; 95% CI, −0.010 to 0.030). Greater cerebrospinal fluid β-amyloid (per 10-pg/mL increase) was associated with increased temporoparietal metabolism (0.005; 95% CI, 0.000–0.010) but not frontal metabolism (0.002; 95% CI, −0.004 to 0.007) in the same patients. In nonconverters, similar relationships were observed except for a positive association of greater WMHs with increased temporoparietal metabolism (0.051; 95% CI, 0.027–0.076). The dissociation of WMHs and cerebrospinal fluid β-amyloid in relation to regional glucose metabolism suggests that these pathologic conditions operate through different and independent pathways in AD that reflect dysfunction in different brain systems. The positive association of greater WMHs with temporoparietal metabolism suggests that these pathologic processes do not co-occur in nonconverters.
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DOI：
10.1007/978-3-642-02498-6_20
发表时间：
2009
期刊：
LECTURE NOTES IN ARTIFICIAL INTELLIGENCE
影响因子：
--
作者：
Schwarz, Christopher;Fletcher, Evan;DeCarli, Charles;Carmichael, Owen
通讯作者：
Carmichael, Owen
影响因子：
9.9
作者：
Jagust, W. J.;Landau, S. M.;Mathis, C. A.
通讯作者：
Mathis, C. A.
影响因子：
2.1
作者：
Kalaria, RN;Ballard, C
通讯作者：
Ballard, C
阿尔茨海默病神经影像计划的磁共振成像核心的最新信息。
影响因子：
14
作者：
Jack, Clifford R., Jr.;Bernstein, Matt A.;Borowski, Bret J.;Gunter, Jeffrey L.;Fox, Nick C.;Thompson, Paul M.;Schuff, Norbert;Krueger, Gunnar;Killiany, Ronald J.;DeCarli, Charles S.;Dale, Anders M.;Carmichael, Owen W.;Tosun, Duygu;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
影响因子：
--
作者：
Carmichael, Owen;Schwarz, Christopher;Drucker, David;Fletcher, Evan;Harvey, Danielle;Beckett, Laurel;Jack, Clifford R.;Weiner, Michael;DeCarli, Charles
通讯作者：
DeCarli, Charles