Solving the chromosome puzzle of aneuploidy in cancer.
Solving the chromosome puzzle of aneuploidy in cancer.
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DOI：
10.1101/gad.348773.121
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发表时间：
2021-08-01
影响因子：
10.5
通讯作者：
Chiarle R
中科院分区：
文献类型：
--
作者：
Chiarle R
本期《展望》讨论了Trakala et al.和Shoshani et al.在本期《基因与发育》中的发现，这些发现利用复杂的小鼠模型来研究非整倍体从早期阶段到肿瘤建立的进展。染色体不稳定性（CIN）和非整倍性是癌细胞的标志，通常与侵袭性和不良结局相关。从历史上看，非整倍体和癌症之间的因果关系一直难以研究，这是由于其内在的复杂性和非整倍体细胞的适应性差。在这个问题的基因与发展，两个同伴论文（Trakala和同事[pp. 1079-1092]和Shoshani和同事[pp. 1093-1108]）利用复杂的小鼠模型来研究非整倍性从早期阶段到建立肿瘤的进展。两个研究小组都观察到，在早期非肿瘤细胞中，非整倍体的特征是随机染色体获得，而已建立的肿瘤显示出定型的核型，只有少数染色体的复发性获得。因此，肿瘤中的非整倍体不是随机的，而是显示出由这两项研究开始揭示的机制诱导的染色体变化的可重复模式。
This Outlook discusses findings by Trakala et al. and Shoshani et al. in this issue of Genes & Development that exploit sophisticated mouse models to study the progression of aneuploidy from early phases to the establishment of tumors. Chromosome instability (CIN) and aneuploidy are hallmarks of cancer cells, typically associated with aggressiveness and poor outcomes. Historically, the causative link between aneuploidy and cancer has been difficult to study due to its intrinsic complexity and the poor fitness of aneuploid cells. In this issue of Genes & Development, two companion papers (Trakala and colleagues [pp. 1079–1092] and Shoshani and colleagues [pp. 1093–1108]) exploited sophisticated mouse models to study the progression of aneuploidy from early phases to established tumors. Both groups observed that, while in the early nontumoral cells aneuploidy is characterized by random chromosomal gains, established tumors display a stereotypic karyotype with recurrent gains of only a few chromosomes. Thus, aneuploidy in tumors is not random but shows reproducible patterns of chromosomal changes induced by mechanisms that these two studies are beginning to unveil.
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影响因子：
10.5
作者：
Trakala M;Aggarwal M;Sniffen C;Zasadil L;Carroll A;Ma D;Su XA;Wangsa D;Meyer A;Sieben CJ;Zhong J;Hsu PH;Paradis G;Ried T;Holland A;Van Deursen J;Amon A
通讯作者：
Amon A
影响因子：
10.5
作者：
Shoshani O;Bakker B;de Haan L;Tijhuis AE;Wang Y;Kim DH;Maldonado M;Demarest MA;Artates J;Zhengyu O;Mark A;Wardenaar R;Sasik R;Spierings DCJ;Vitre B;Fisch K;Foijer F;Cleveland DW
通讯作者：
Cleveland DW
影响因子：
3.9
作者：
Bignold, Leon P.;Coghlan, Brian L. D.;Jersmann, Hubertus Pa.
通讯作者：
Jersmann, Hubertus Pa.
影响因子：
50.3
作者：
Taylor AM;Shih J;Ha G;Gao GF;Zhang X;Berger AC;Schumacher SE;Wang C;Hu H;Liu J;Lazar AJ;Cancer Genome Atlas Research Network;Cherniack AD;Beroukhim R;Meyerson M
通讯作者：
Meyerson M
影响因子：
11.8
作者：
Santaguida S;Richardson A;Iyer DR;M'Saad O;Zasadil L;Knouse KA;Wong YL;Rhind N;Desai A;Amon A
通讯作者：
Amon A