Interactions Between Adiponectin-Pathway Polymorphisms and Obesity on Postmenopausal Breast Cancer Risk Among African American Women: The WHI SHARe Study.
Interactions Between Adiponectin-Pathway Polymorphisms and Obesity on Postmenopausal Breast Cancer Risk Among African American Women: The WHI SHARe Study.
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DOI：
10.3389/fonc.2021.698198
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发表时间：
2021
影响因子：
4.7
通讯作者：
Jung SY
中科院分区：
文献类型：
--
作者：
Nam GE;Zhang ZF;Rao J;Zhou H;Jung SY
血清脂联素水平降低与绝经后妇女肥胖和乳腺癌风险增加有关。然而，在非裔美国人（AA）妇女中，与脂联素表型、肥胖和乳腺癌风险相关的遗传变异之间的相互作用尚不清楚。我们检查了32个单核苷酸多态性（SNPs），这些单核苷酸多态性是以前在全基因组关联和血清脂联素水平复制研究中发现的，使用的数据来自妇女健康倡议SNP健康协会资源中的7,991名AA绝经后妇女。根据肥胖状态分层，我们确定了18个与乳腺癌风险相关的脂联素相关SNPs。在BMI ≥ 30 kg/m2的女性中，FER rs 10447248的次要TT基因型具有较高的乳腺癌风险。在乳腺癌风险的加性量表上观察到肥胖和ADIPOQ rs6773957的CT基因型之间的相互作用（由于相互作用的相对超额风险，0.62; 95%CI，0.32-0.92）。BMI ≥ 30 kg/m2和OR 8 S1 rs 11168618 TC基因型对乳腺癌风险的联合作用大于独立作用之和。我们使用绝经后AA妇女最广泛的数据之一，证明肥胖在SNPs对乳腺癌风险增加的影响中起着重要的作用。结果表明，脂联素遗传变异作为肥胖相关生物标志物的潜在用途，可用于告知乳腺癌风险更高的AA女性，并促进行为干预，如体重控制，对那些具有风险基因型的女性。
A decreased level of serum adiponectin is associated with obesity and an increased risk of breast cancer among postmenopausal women. Yet, the interplay between genetic variants associated with adiponectin phenotype, obesity, and breast cancer risk is unclear in African American (AA) women. We examined 32 single-nucleotide polymorphisms (SNPs) previously identified in genome-wide association and replication studies of serum adiponectin levels using data from 7,991 AA postmenopausal women in the Women’s Health Initiative SNP Health Association Resource. Stratifying by obesity status, we identified 18 adiponectin-related SNPs that were associated with breast cancer risk. Among women with BMI ≥ 30 kg/m2, the minor TT genotype of FER rs10447248 had an elevated breast cancer risk. Interaction was observed between obesity and the CT genotype of ADIPOQ rs6773957 on the additive scale for breast cancer risk (relative excess risk due to interaction, 0.62; 95% CI, 0.32–0.92). The joint effect of BMI ≥ 30 kg/m2 and the TC genotype of OR8S1 rs11168618 was larger than the sum of the independent effects on breast cancer risk. We demonstrated that obesity plays a significant role as an effect modifier in an increased effect of the SNPs on breast cancer risk using one of the most extensive data on postmenopausal AA women. The results suggest the potential use of adiponectin genetic variants as obesity-associated biomarkers for informing AA women who are at greater risk for breast cancer and also for promoting behavioral interventions, such as weight control, to those with risk genotypes.
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影响因子：
3.7
作者：
Comuzzie AG;Cole SA;Laston SL;Voruganti VS;Haack K;Gibbs RA;Butte NF
通讯作者：
Butte NF
影响因子：
5.3
作者：
Heid, Iris M.;Henneman, Peter;Hicks, Andrew;Coassin, Stefan;Winkler, Thomas;Aulchenko, Yurii S.;Fuchsberger, Christian;Song, Kijoung;Hivert, Marie-France;Waterworth, Dawn M.;Timpson, Nicholas J.;Richards, J. Brent;Perry, John R. B.;Tanaka, Toshiko;Amin, Najaf;Kollerits, Barbara;Pichler, Irene;Oostra, Ben A.;Thorand, Barbara;Frants, Rune R.;Illig, Thomas;Dupuis, Josee;Glaser, Beate;Spector, Tim;Guralnik, Jack;Egan, Josephine M.;Florez, Jose C.;Evans, David M.;Soranzo, Nicole;Bandinelli, Stefania;Carlson, Olga D.;Frayling, Timothy M.;Burling, Keith;Smith, George Davey;Mooser, Vincent;Ferrucci, Luigi;Meigs, James B.;Vollenweider, Peter;van Dijk, Ko Willems;Pramstaller, Peter;Kronenberg, Florian;van Duijn, Cornelia M.
通讯作者：
van Duijn, Cornelia M.
DOI：
10.1073/pnas.0403621101
发表时间：
2004-07-06
影响因子：
11.1
作者：
Biswas, DK;Shi, Q;Iglehart, JD
通讯作者：
Iglehart, JD
影响因子：
9.8
作者：
Jee, Sun Ha;Sull, Jae Woong;Beaty, Terri H.
通讯作者：
Beaty, Terri H.
影响因子：
2.1
作者：
Isabel Pena-Cano, Maria;Saucedo, Renata;Lopez, Adriana
通讯作者：
Lopez, Adriana